2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. cGAS-IN-3

cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].br/.

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cGAS-IN-3 Chemical Structure

cGAS-IN-3 Chemical Structure

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cGAS-IN-3 Related Antibodies

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Description

cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].br/[16][1].

IC50 & Target

cGAS[1]
In Vitro

The inhibitory potency (IC50) of cGAS-IN-3 against cGAS in mouse RAW-Lucia cells is 2.87 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cGAS-IN-3 Related Antibodies
In Vivo

cGAS-IN-3 (30 mg/kg; po; single dose) has preventive effects on LPS-induced acute lung injury (ALI) mouse model and can effectively reduce inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury (ALI) mice model[1]
Dosage: 30 mg/kg
Administration: po; single dose and 0.5 h prior to ALI modeling; while ALI was induced by intratracheal instillation of 2 mg/kg LPS
Result: Alleviated the severity of lung injury, presented by the ameliorated pathological changes
Relieved pulmonary edema, and the reduced number of immune cells in BALF.
Molecular Weight

469.31

Formula

C21H20Cl2F2N4O2
SMILES

ClC1=CC(C2=NN(C=C2)C(F)F)=C3C(NC4=C3C[C@]5(CC4)CCN(C5)C(CO)=O)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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cGAS-IN-3 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAS-IN-3Cyclic GMP-AMP SynthasecGASInhibitorinhibitorinhibit

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