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Furegrelate sodium (Synonyms: U-63557A)

Cat. No.: HY-106080A Purity: >99.0%
Handling Instructions

Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent.

For research use only. We do not sell to patients.

Furegrelate sodium Chemical Structure

Furegrelate sodium Chemical Structure

CAS No. : 85666-17-7

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10 mM * 1 mL in DMSO USD 133 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent[1][2].

In Vivo

Furegrelate Sodium (U-63557A) (1-5 mg/kg; Oral) prevents blockage of the coronary artery[1].
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation[1].
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature[2].
Furegrelate also is orally available, has a long half-life of 4.2–5.8 hours in adult humans (compared to several other therapies for PAH including nitric oxide and prostacyclin analogs), and reportedly is highly specific for its target enzyme[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel dogs (19-30 kg)[1]
Dosage: 1-5 mg/kg
Administration: Oral (via a gastric tube)
Result: Prevented blockage of the coronary artery.
Molecular Weight

275.23

Formula

C₁₅H₁₀NNaO₃

CAS No.

85666-17-7

SMILES

O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

FuregrelateU-63557AOthersorallyavailablehumanplateletantiplateletstenosedcoronaryarteriespulmonaryarterialhypertensionInhibitorinhibitorinhibit

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Furegrelate sodium
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