85666-17-7
85666-17-7
Chemical Structure
Furegrelate sodium
Synonym(s): U-63557A
- CAS No.: 85666-17-7
- Formula:C15H10NNaO3
- Molecular Weight:275.23
IUPAC Name: sodium 5-(pyridin-3-ylmethyl)benzofuran-2-carboxylate
InChIKey: XBTIPIZROJAKOJ-UHFFFAOYSA-M
SMILES: O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O[Na]
Biological Activity: Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent[1][2].
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Furegrelate sodium | 99.69% | Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent. | ||||||||||||||||||||
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Furegrelate sodium (Standard) | ≥98% | Furegrelate (sodium) (Standard) is the analytical standard of Furegrelate (sodium). This product is intended for research and analytical applications. Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-106080Furegrelate -
Similarity Score 0.63
HY-183483OKY-1581 -
Similarity Score 0.62
HY-W207699MAO-B-IN-46 -
Similarity Score 0.61
HY-149008α-Amylase-IN-3 -
Similarity Score 0.60
HY-Z0539RMethyl 5-nitro-2-benzofurancarboxylate (Standard) -
Similarity Score 0.60
HY-77058Ethyl 5-piperazin-1-ylbenzofuran-2-carboxylate -
Similarity Score 0.59
HY-I0056Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate hydrochloride -
Similarity Score 0.58
![Dibenzo[b,d]furan-2,8-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w1049911.gif)
HY-W1049911Dibenzo[b,d]furan-2,8-dicarboxylic acid -
Similarity Score 0.58
HY-77058A5-(1-Piperazinyl)-2-benzofurancarboxylic acid ethyl ester dihydrochloride hydrate -
Explore the MedChemAI to find more analogs
![Dibenzo[b,d]furan-2,8-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w1049911.gif)
References
- [1]. Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26(2):325-42. [Content Brief]
- [2]. Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200. [Content Brief]
