2. Metabolic Enzyme/Protease
  3. Fatty Acid Synthase (FASN)
  4. GSK837149A

GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer.

For research use only. We do not sell to patients.

GSK837149A Chemical Structure

GSK837149A Chemical Structure

CAS No. : 13616-29-0

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Based on 1 publication(s) in Google Scholar

GSK837149A Related Antibodies

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Description

GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2].

IC50 & Target

Ki: 30 nM (type I FASN)[1]
In Vitro

GSK837149A (0.1 nM-0.1 mM) shows an increasing inhibition effect on acetyl-CoA/malonyl-CoA, and acetoacetyl-CoA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK837149A Related Antibodies
Molecular Weight

554.60

Formula

C23H22N8O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C=C1)S(=O)(NC2=NC=CC(C)=N2)=O)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC(C)=N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GSK837149A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK837149A13616-29-0Fatty Acid Synthase (FASN)Inhibitorinhibitorinhibit

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