TRIB1 Protein, Human (sf9, GST)
TRIB1 Protein, Human (sf9, GST) is the recombinant human-derived TRIB1, expressed by Sf9 insect cells , with GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TRIB1 Protein, Human (sf9, GST) is the recombinant human-derived TRIB1, expressed by Sf9 insect cells , with GST labeled tag. ,
Background
TRIB1 is a pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. On tRNAs, it acts on positions 27/28 in the anticodon stem and positions 34/36 in the anticodon of intron-containing tRNAs. For mRNAs, it modifies transcripts with the consensus sequence 5'-UGUAG-3'. Additionally, TRIB1 regulates pre-mRNA splicing by mediating pseudouridylation near alternative splicing regions, directly influencing mRNA splicing and 3'-end processing. It also modulates nuclear receptor activity through pseudouridylation of SRA1 mRNA.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST
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Accession
Q9Y606 (M1-D427)
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Gene ID80324
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Protein Length
Full Length
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Synonyms
PUS1; Pseudouridylate Synthase 1; Pseudouridine Synthase 1; TRNA-Uridine Isomerase I; TRNA Pseudouridine(38-40) Synthase; Mitochondrial Myopathy And Sideroblastic Anemia 1; Pseudouridylate Synthase 1 Homolog; TRNA Pseudouridine Synthase A, Mitochondrial;
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AA Sequence
MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
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Molecular Weight
Approximately 70 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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