Prostaglandin E2 Inhibitor 3
Based on 1 Customer Validation
Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice.
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- CAS No.: 3054217-03-4
- Formule: C21H14BrN3O2S
- Masse moléculaire:452.32
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| PMNL | IC50 |
4.9 μM
Compound: 3
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Inhibition of Leukotriene biosynthesis in human PMNL cells preincubated for 10 mins followed by Ca2+-ionophore A23187 addition and measured after 10 mins by RP-HPLC analysis
Inhibition of Leukotriene biosynthesis in human PMNL cells preincubated for 10 mins followed by Ca2+-ionophore A23187 addition and measured after 10 mins by RP-HPLC analysis
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[PMID: 36655121] |
| PMNL | IC50 |
5.2 μM
Compound: 3
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Inhibition of Leukotriene biosynthesis in human PMNL cells preincubated for 10 mins followed by Ca2+-ionophore A23187 and arachidonic acid addition and measured after 10 mins by RP-HPLC analysis
Inhibition of Leukotriene biosynthesis in human PMNL cells preincubated for 10 mins followed by Ca2+-ionophore A23187 and arachidonic acid addition and measured after 10 mins by RP-HPLC analysis
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[PMID: 36655121] |
Chemical Information
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CAS No. 3054217-03-4
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Appearance Solid
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Masse moléculaire 452.32
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Formule C21H14BrN3O2S
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Color Light brown to brown
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SMILES
O=C(C1=C(Br)C=CC=C1)NC2=NN=C(C3=CC=C(C4=CC(O)=CC=C4)C=C3)S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Prostaglandin E2 Inhibitor 3 Related Classifications
HY-169858 Related Classifications
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