Art. -Nr.: HY-18732C

L-NMMA hydrochloride

(Synonyms: Tilarginine hydrochloride; Methylarginine hydrochloride)

11 Cited Publications

Kundenbewertung

Based on 11 publication(s) in Google Scholar

L-NMMA (Tilarginine) hydrochloride is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA hydrochloride inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA hydrochloride alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA hydrochloride is applicable to research related to nociception, bone cancer pain, and myopia.

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CAS. Nr.: 156706-47-7
Formel: C₇H₁₇ClN₄O₂
Molecular Weight:224.69

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

L-NMMA hydrochloride Chemical Structure

CAS. Nr.: 156706-47-7

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (11)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vivo

L-NMMA (50 µg; i.t.; single administration) hydrochloride significantly alleviates bone cancer-induced mechanical allodynia and thermal hyperalgesia in mice at 2 and 12 h post-treatment^[1].
L-NMMA (20 nmol; intravitreal injection; once every other day; 2 to 4 weeks) hydrochloride alleviates choroidal fibrosis and delays myopia progression by inhibiting the NO signaling pathway in lens-induced myopic guinea pigs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeJ (male, 4-6 weeks old, 20-22 g, intramedullary inoculation of NCTC 2472 osteosarcoma cells)^[1]
Dosage:

50 µg
Administration:

i.t.; single administration
Result:

Increased paw withdrawal mechanical threshold to 0.90 g at 2 h and 0.63 g at 12 h compared to 0.40 g in vehicle-treated tumor mice.
Increased paw withdrawal thermal latency to 16.2 sec at 2 h and 12.7 sec at 12 h compared to 10.1 sec in vehicle-treated tumor mice.
Lost analgesic effect at 24 h post-administration.

Animal Model:

British short-haired tricolor guinea pigs (2-week-old, 110-130 g, lens-induced myopia model)^[2]
Dosage:

20 nmol
Administration:

intravitreal injection; once every other day; 2 and 4 weeks
Result:

Increased refraction significantly after 2 and 4 weeks compared to the lens-induced myopia group.
Reduced the D-value of axial length between the myopic eye and control eye significantly after 2 and 4 weeks compared to the lens-induced myopia group.
Increased choroidal thickness to 80.62 μm at 4 weeks compared to 63.54 μm in the lens-induced myopia group.
Reduced degradation of choroidal pigment particles and narrowed particle gaps compared to the lens-induced myopia group.
Produced denser, more orderly choroidal tissue structure compared to the lens-induced myopia group.
Reduced choroidal fibrosis compared to the lens-induced myopia group.
Lowered gene expression levels of NOS1, NOS3, TGF-β1, COL I, and α-SMA significantly after 2 and 4 weeks compared to the lens-induced myopia group.
Lowered protein levels of NOS1, NOS3, TGF-β1, COL I, and α-SMA significantly after 2 and 4 weeks compared to the lens-induced myopia group.
Reduced expression of COL I, α-SMA, NOS1, NOS3, and TGF-β1 in choroidal tissues compared to the lens-induced myopia group.

Chemical Information

CAS. Nr. 156706-47-7
Molecular Weight 224.69
Formel C₇H₁₇ClN₄O₂
SMILES

N[C@@H](CCCNC(NC)=N)C(O)=O.Cl
Synonyms

Tilarginine hydrochloride; Methylarginine hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (11)

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Cell Metab

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology. [Abstract]

2025 Jan 7;37(1):291-304.e9. PMID: 39413790
Nat Immunol

Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. [Abstract]

2023 Jan;24(1):162-173. PMID: 36471170

L-NMMA hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

L-NMMA acetate (200 μM; 48 h) led to elevating ammonia and inhibiting CD8⁺ T_M cell induction, in parallel with the inhibition of NO production.

L-NMMA hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

L-NMMA acetate (100 μM; 48 h) led to the accumulation of m + 1 arginine and a slowed nitrogen flow in CD8⁺ T_M cells.

L-NMMA hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

L-NMMA acetate (100 μM; 48 h) blocked formation of CD8⁺ T_M cells.

L-NMMA hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

CD8⁺ T_M cells were treated with L-NMMA acetate (100 μM; 48 h) and the level of urea was analyzed.

L-NMMA hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

IL-15-derived CD8⁺ T_M cells were treated with L-NMMA acetate (100 μM; 48 h), then were cultured with [U4] ¹⁵N-arginine for 6 hours and LC-MS/MS analysis was performed for m + 2, m + 3 citrulline, m + 2 ornithine and m + 2 urea.
Nat Commun

An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. [Abstract]

2021 May 10;12(1):2587. PMID: 33972537
Cell Mol Gastroenterol Hepatol

Citrulline inhibits Clostridioides difficile infection with anti-inflammatory effects. [Abstract]

2025;19(6):101474. PMID: 39923847
Cell Mol Gastroenterol Hepatol

Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. [Abstract]

2021;11(3):683-696. PMID: 33075564
Life Sci

Identification and regulation of a novel leptin receptor-linked enhancer during zebrafish ventricle regeneration. [Abstract]

2025 Feb 15:363:123415. PMID: 39864617
EMBO Rep

Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation. [Abstract]

2025 Oct 20. PMID: 41116072
Front Cell Dev Biol

mTOR Signaling Regulates the Development and Therapeutic Efficacy of PMN-MDSCs in Acute GVHD. [Abstract]

2021 Dec 23;9:741911. PMID: 35004668
FASEB J

Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging. [Abstract]

2025 Sep 30;39(18):e71057. PMID: 40955599
Eur J Immunol

Fibroblast transdifferentiation promotes conversion of M1 macrophages and replenishment of cardiac resident macrophages following cardiac injury in mice. [Abstract]

2020 Jun;50(6):795-808. PMID: 32068249
Theriogenology

Nitric oxide regulates spindle dynamics to modulate the maturation of goat oocytes. [Abstract]

2025 Oct 1:245:117517. PMID: 40460471

Reinheit & Dokumentation

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Reinheit: 99.98%

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Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Frey C, et al., L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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L-NMMA hydrochloride

11 Cited Publications

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L-NMMA hydrochloride

Publications Citing Use of MedChemExpress (MCE) L-NMMA hydrochloride

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (11)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L-NMMA hydrochloride Related Classifications

HY-18732C Related Classifications