Isofouquierol 

Isofouquierol is a selective inhibitor targeting nitric oxide (NO) production with anti-inflammatory activity. Isofouquierol blocks NO overproduction by inhibiting the inducible nitric oxide synthase (iNOS)-related pathway. Isofouquierol can be used in the study of inflammation-related diseases (such as chronic inflammation, immune disorders)^[1][2].

Isofouquierol (30 μM, 100 μM) inhibits NO production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages by 18.4% (30 μM) and 86.6% (100 μM), respectively ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

460.73

C₃₀H₅₂O₃

53822-99-4

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]3([H])[C@@](C)(O)C/C=C/C(C)(O)C)C)([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pakhathirathien C, et al. Dammarane triterpenes from the hypocotyls and fruits of Ceriops tagal. J Nat Prod. 2005 Dec;68(12):1787-9.  [Content Brief]

  [2]. Yoshikawa M, et al. Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Chem Pharm Bull (Tokyo). 2009 Sep;57(9):957-64.  [Content Brief]