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PF-06928215 

Cat. No.: HY-114182 Purity: >99.0%
Handling Instructions

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

For research use only. We do not sell to patients.

PF-06928215 Chemical Structure

PF-06928215 Chemical Structure

Size Price Stock
5 mg USD 210 Get quote

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd)[1].

IC50 & Target

IC50: 4.9 μM (cGAS)[1]
Kd: 0.2 μM[1]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (87.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6288 mL 13.1441 mL 26.2881 mL
5 mM 0.5258 mL 2.6288 mL 5.2576 mL
10 mM 0.2629 mL 1.3144 mL 2.6288 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

380.40

Formula

C₂₀H₂₀N₄O₄

SMILES

OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[[email protected]]4CCCC[[email protected]]4C(O)=O)=O)C=NN13

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
PF-06928215
Cat. No.:
HY-114182
Quantity:

PF-06928215

Cat. No.: HY-114182