NP-184
NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases.
For research use only. We do not sell to patients.
- CAS No.: 78706-11-3
- Formula: C12H10N2O
- Molecular Weight:198.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
IC50: 4.3 μM (TXA2 synthase)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
102.54 μM
Compound: 4b
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
|
[PMID: 28505536] |
| MCF7 | IC50 |
14 μg/mL
Compound: 3b
|
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 24576797] |
| MCF7 | IC50 |
55.55 μM
Compound: 4b
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
|
[PMID: 28505536] |
Chemical Information
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CAS No. 78706-11-3
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Appearance Solid
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Molecular Weight 198.22
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Formula C12H10N2O
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3N2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)