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Pathways Recommended: Vitamin D Related/Nuclear Receptor
Results for "

IFNα subtype D/1

" in MedChemExpress (MCE) Product Catalog:

1396

Inhibitors & Agonists

12

Screening Libraries

4

Fluorescent Dyes

5

Biochemical Assay Reagents

71

Peptides

42

Inhibitory Antibodies

108

Natural
Products

82

Recombinant Proteins

239

Isotope-Labeled Compounds

51

Antibodies

5

Click Chemistry

70

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12520A
    SKF 38393 hydrochloride
    15+ Cited Publications

    (±)-SKF-38393 hydrochloride; SKF-38393A

    		 Dopamine Receptor Neurological Disease
    SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM [1].
    SKF 38393 hydrochloride
  • HY-130413
    Protectin D1

    Neuroprotectin D1; NPD1

    		 Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders [1] .
    Protectin D1
  • HY-125527
    Resolvin D1
    1 Publications Verification

    RvD1

    		 Endogenous Metabolite Inflammation/Immunology
    Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages [1] .
    Resolvin D1
  • HY-112624A
    Dextran T1 (MW 1,000)

    Dextran 1; Dextran D1; Dextran T1(MW 800-1200)

    		 Biochemical Assay Reagents Others
    Dextran T1 (Dextran 1; Dextran D1) (with a molecular weight of 1,000) is a dehydrated glucose polymer with an average molecular weight of 1,000. Dextran T1 (MW 1,000) has excellent biodegradability and biocompatibility, and can be used as a nanobody carrier scaffold and a freeze-drying protectant. Dextran T1 (MW 1,000) promotes the retention of circulating tumor cells in the capillary bed [1] .
    Dextran T1 (MW 1,000)
  • HY-10435A
    SKF-82958 hydrobromide
    4 Publications Verification

    (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide

    		 Dopamine Receptor Neurological Disease
    SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) [1].
    SKF-82958 hydrobromide
  • HY-128770
    LY3154207
    2 Publications Verification

    		 Dopamine Receptor Neurological Disease
    LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM) [1].
    LY3154207
  • HY-145119AS
    Mindeudesivir hydrobromide

    VV116; GS-621763-d1 hydrobromide

    		 SARS-CoV RSV Influenza Virus Infection
    Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 [1] .
    Mindeudesivir hydrobromide
  • HY-P99219
    Sifalimumab

    MEDI-545; MDX 1103

    		 IFNAR Inflammation/Immunology
    Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research [1] .
    Sifalimumab
  • HY-B0892S4
    Benzyl alcohol-d1

    Benzenemethanol-d1

    		 Endogenous Metabolite Others
    Benzyl alcohol-d1 is the deuterium labeled Benzyl alcohol [1].
    Benzyl alcohol-d1
  • HY-111428
    Phleomycin D1
    2 Publications Verification

    PLM D1

    		 Antibiotic Infection
    Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase [1] .
    Phleomycin D1
  • HY-101299B
    Dihydrexidine hydrochloride
    5 Publications Verification

    DAR-0100 hydrochloride

    		 Dopamine Receptor Neurological Disease
    Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity [1] . Dihydrexidine hydrochloride can stimulate YAP phosphorylation .
    Dihydrexidine hydrochloride
  • HY-N0322S7
    Cholesterol-d1

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite Endocrinology
    Cholesterol-d1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins [1] . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
    Cholesterol-d1
  • HY-111745
    Tyk2-IN-5

    		JAK Inflammation/Immunology
    Tyk2-IN-5 (compound 6) is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis [1].
    Tyk2-IN-5
  • HY-115553
    DETQ

    		Dopamine Receptor Neurological Disease
    DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor [1].
    DETQ
  • HY-125527A
    17(R)-Resolvin D1
    1 Publications Verification

    17(R)-RvD1; AT-RvD1

    		 TRP Channel Inflammation/Immunology
    17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells [1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy .
    17(R)-Resolvin D1
  • HY-170331
    IFNα-IN-1

    		IFNAR Inflammation/Immunology
    IFNα-IN-1 (AJ2-18) is a IFNα inhibitor that inhibits IFN-α production. IFNα-IN-1 can be used for research of inflammation [1].
    IFNα-IN-1
  • HY-125527S
    Resolvin D1-d5

    RvD1-d5

    		 Isotope-Labeled Compounds Endogenous Metabolite Inflammation/Immunology
    Resolvin D1-d5 is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages [1] .
    Resolvin D1-d5
  • HY-101299A
    Dihydrexidine

    DAR-0100

    		 Dopamine Receptor YAP Neurological Disease
    Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity [1] . Dihydrexidine can stimulate YAP phosphorylation .
    Dihydrexidine
  • HY-P11147
    IL13Rα2 D1

    		Interleukin Related FAK Src Akt ERK MMP Cancer
    IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor. IL13Rα2 D1 can inhibit IL-13-induced cell adhesion, migration, invasion, and proliferation. IL13Rα2 D1 can inhibit FAK, Src, AKT, ERK1/2 phosphorylation, and MMP expression. IL13Rα2 D1 can be used for research on cancers such as colorectal cancer [1].
    IL13Rα2 D1
  • HY-P10405A
    TAT-D1 peptide acetate

    		Dopamine Receptor Neurological Disease
    TAT-D1 peptide acetate is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide acetate disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide acetate produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide acetate can be used in the research of psychostimulant addiction, depression and anxiety disorders [1] .
    TAT-D1 peptide acetate
  • HY-19545B
    (S)-SCH-23390 hydrochloride

    SCH-23388 hydrochloride

    		 Dopamine Receptor Neurological Disease
    (S)-SCH-23390 hydrochloride is the S-enantiomer of SCH-23390 (HY-19545). SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively) [1].
    (S)-SCH-23390 hydrochloride
  • HY-W020018S1
    N-Methylacetamide-d1

    		Isotope-Labeled Compounds Others
    N-Methylacetamide-d1 is the deuterium labeled N-Methylacetamide [1].
    N-Methylacetamide-d1
  • HY-W016577S4
    1-Bromoheptane-d1

    n-Heptyl bromide-d1

    		 Isotope-Labeled Compounds Others
    1-Bromoheptane-d1 is the deuterium labeled 1-Bromoheptane [1].
    1-Bromoheptane-d1
  • HY-145119S
    Mindeudesivir

    VV116 free base; GS-621763-d1

    		 Isotope-Labeled Compounds Others
    GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) [1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
    Mindeudesivir
  • HY-175983
    JAK1/TYK2-IN-5

    		JAK Cancer
    JAK1/TYK2-IN-5 (compound A1) is a JAK1/TYK2 inhibitor with Ki values of 0.0044 nM, 0.02 nM, 6.9 μM, 0.79 μM, 0.21 μM and 0.55 μM for TYK2 JH2, JAK1 JH2, JAK1 JH1, JAK2 JH1, JAK3 JH1 and TYK2 JH1, respectiverly. JAK1/TYK2-IN-5 inhibts IFNα induced TYK2/JAK1-mediated STAT activation [1].
    JAK1/TYK2-IN-5
  • HY-W088065S1
    Sodium formate-13C,d1

    		Isotope-Labeled Compounds Others
    Sodium formate- 13C,d1 is the deuterium and 13C labeled Sodium formate.Sodium formate is a biochemical assay reagent. Sodium formate can react with zinc sources (such as ZnCl2) on the surface of alpha alumina support to form a zinc oxide layer. Sodium formate acts as a deprotonating agent, promoting the deprotonation of ligands (such as 2-methylimidazole) at high temperatures. Sodium formate provides the required reducing force in the catalytic oxidation of methane to methanol by methane monooxygenase (sMMO) and inhibits further oxidation of methanol [1] .
    Sodium formate-13C,d1
  • HY-B0389S4
    D-Glucose-d1-2

    Glucose-d1-2; D-(+)-Glucose-d1-2; Dextrose-d1-2

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
    D-Glucose-d1-2
  • HY-128031
    Resolvin D1 methyl ester

    RvD1 methyl ester

    		 Drug Derivative Metabolic Disease
    Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels [1].
    Resolvin D1 methyl ester
  • HY-113096
    Prostaglandin D1

    PGD1

    		 Endogenous Metabolite Metabolic Disease
    Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC50 value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research [1] .
    Prostaglandin D1
  • HY-P1758
    IFN-α Receptor Recognition Peptide 1

    IRRP1

    		 IFNAR Infection
    IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions [1].
    IFN-α Receptor Recognition Peptide 1
  • HY-N16465
    Cinnamtannin D1

    		Apoptosis Reactive Oxygen Species (ROS) STAT Inflammation/Immunology
    Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) [1] .
    Cinnamtannin D1
  • HY-P10405
    TAT-D1 peptide

    		Dopamine Receptor Neurological Disease
    TAT-D1 peptide is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide can be used in the research of psychostimulant addiction, depression and anxiety disorders [1] .
    TAT-D1 peptide
  • HY-W865379
    (S)-Avadomide-d1

    SP-3164; CC 122-d1

    		 Isotope-Labeled Compounds Others
    (S)-Avadomide-d1 (SP-3164; CC 122-d1) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).
    (S)-Avadomide-d1
  • HY-W016174S
    Diphenylsulfane-d1

    		Isotope-Labeled Compounds Others
    Diphenylsulfane-d1 is the deuterium labeled Diphenylsulfane [1].
    Diphenylsulfane-d1
  • HY-W712650
    Triethylsilane-d1

    		Isotope-Labeled Compounds Others
    Triethylsilane-d1 is deuterium labeled Triethylsilicon hydride [1].
    Triethylsilane-d1
  • HY-175001
    D1/D5 Receptor agonist-1

    		Dopamine Receptor Arrestin Neurological Disease
    D1/D5 Receptor agonist-1 is a highly brain-penetrant and orally active D1/D5 receptor agonist. D1/D5 Receptor agonist-1 maintains considerable efficacy in the cAMP pathway and in β-arrestin recruitment, with EC50s of 3.7 nM (D1R cAMP), 91 nM (D1R β-arrestin), 129 nM (D1R internalization) and a Ki of 111 nM (D1R binding affinity). D1/D5 Receptor agonist-1 inhibits β-arrestin signaling in a rat with L-DOPA (HY-N0304) induced dyskinesias. D1/D5 Receptor agonist-1 can be used for the study of Parkinson’s disease [1].
    D1/D5 Receptor agonist-1
  • HY-109037S2
    Mavacamten-d1

    MYK461-d1; SAR439152-d1

    		 Isotope-Labeled Compounds Myosin Cardiovascular Disease
    Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
    Mavacamten-d1
  • HY-W014292S
    3-Benzyloxybenzaldehyde-α-d1

    		Isotope-Labeled Compounds Others
    3-Benzyloxybenzaldehyde-α-d1 is the deuterium labeled 3-Benzyloxybenzaldehyde [1].
    3-Benzyloxybenzaldehyde-α-d1
  • HY-W400722
    Sodium 3-methyl-2-oxobutanoate-13C5,d1

    		Isotope-Labeled Compounds Others
    Sodium 3-methyl-2-oxobutanoate- 13C5,d1 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate [1].
    Sodium 3-methyl-2-oxobutanoate-13C5,d1
  • HY-19545
    SCH-23390

    R-(+)-SCH-23390

    		 Dopamine Receptor Neurological Disease
    SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system [1] .
    SCH-23390
  • HY-160144S2
    (rac)-Lomedeucitinib

    (rac)-BMS-986322

    		 Drug Isomer Others
    (rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus [1] .
    (rac)-Lomedeucitinib
  • HY-170645
    Neuroprotectin D1 methyl ester

    		Drug Intermediate Neurological Disease
    Neuroprotectin D1 methyl ester is an esterified form of Protectin D1 (HY-130413). Neuroprotectin D1 methyl ester is an intermediate in the synthesis of Protectin D1.
    Neuroprotectin D1 methyl ester
  • HY-N14076
    Monamycin D1

    		Antibiotic Bacterial Infection
    Monamycin D1 is an ester peptide antibiotic. Monamycin D1 has activity against Gram-positive bacteria [1].
    Monamycin D1
  • HY-10435
    SKF-82958

    (±)-SKF-82958; Chloro-APB

    		 Dopamine Receptor Neurological Disease
    SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) [1].
    SKF-82958
  • HY-N15531
    Icariside D1

    		Estrogen Receptor/ERR Inflammation/Immunology Cancer
    Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers [1].
    Icariside D1
  • HY-163373
    13,14-Dihydro-15-keto prostaglandin D1

    		Drug Derivative Endocrinology
    13,14-Dihydro-15-keto prostaglandin D1 is a derivative of prostaglandin D1 [1].
    13,14-Dihydro-15-keto prostaglandin D1
  • HY-N12295
    Ciwujianoside D1

    		Others Inflammation/Immunology
    Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells [1].
    Ciwujianoside D1
  • HY-134860
    Prostaglandin D1 alcohol

    		Prostaglandin Receptor Metabolic Disease
    Prostaglandin D1 (PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl [1].
    Prostaglandin D1 alcohol
  • HY-N15115
    Polymyxin D1

    		Antibiotic Bacterial Infection
    Polymyxin D1 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria [1].
    Polymyxin D1
  • HY-142704
    BRD4 D1-IN-1

    		Epigenetic Reader Domain Cancer
    BRD4 D1-IN-1 is a selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-1 has 18 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC [1].
    BRD4 D1-IN-1

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