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Cat. No.: HY-120687

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A68930

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis.

For research use only. We do not sell to patients.

CAS No.: 130465-45-1
Formula: C₁₆H₁₇NO₃
Molecular Weight:271.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

A68930 Chemical Structure

CAS No.: 130465-45-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis^[1].

IC₅₀ & Target

D₁ Receptor

All Dopamine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Pituitary gland cell	EC₅₀	10200 nM Compound: 22	Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland	[PMID: 1652023]

In Vitro

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein^[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression^[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

16HBE14o- or NCI-H292 cells
Concentration:

1 μM
Incubation Time:

5~60 minutes
Result:

Significantly increased phosphorylation of CREB.

RT-PCR^[1]

Cell Line:

NCI-H292 cells
Concentration:

1 μM
Incubation Time:

48 hours
Result:

Induced MUC5AC mRNA expression.

Immunofluorescence^[1]

Cell Line:

NCI-H292 cells
Concentration:

1 μM
Incubation Time:

48 hours
Result:

The mRNA data of MUC5AC, MUC5AC protein expression were increased.

Chemical Information

CAS No. 130465-45-1
Molecular Weight 271.31
Formula C₁₆H₁₇NO₃
SMILES

OC1=C2C[C@H](O[C@H](C2=CC=C1O)CN)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

bioRxiv

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection. [Abstract]

2026 Jan 6:2026.01.06.697936. PMID: 41542404

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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