A68930

Cat. No.: HY-120687: FAQs
Data Sheet Handling Instructions

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A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (A68930 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

A68930 Chemical Structure

CAS No. : 130465-45-1

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Other Forms of A68930:

A68930 hydrochloride In-stock

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis^[1].

IC₅₀ & Target

D₁ Receptor

In Vitro

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein^[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression^[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	16HBE14o- or NCI-H292 cells
Concentration:	1 μM
Incubation Time:	5~60 minutes
Result:	Significantly increased phosphorylation of CREB.

RT-PCR^[1]

Cell Line:	NCI-H292 cells
Concentration:	1 μM
Incubation Time:	48 hours
Result:	Induced MUC5AC mRNA expression.

Immunofluorescence^[1]

Cell Line:	NCI-H292 cells
Concentration:	1 μM
Incubation Time:	48 hours
Result:	The mRNA data of MUC5AC, MUC5AC protein expression were increased.

Molecular Weight

271.31

Formula

C₁₆H₁₇NO₃

CAS No.

130465-45-1

SMILES

OC1=C2C[C@H](O[C@H](C2=CC=C1O)CN)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. [Content Brief]

A68930 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A68930130465-45-1A 68930A-68930Dopamine ReceptorbronchiectasisMUC5ACNCI-H292CREBcAMPInhibitorinhibitorinhibit

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