2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-1

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA.

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Influenza A virus-IN-1 Chemical Structure

Influenza A virus-IN-1 Chemical Structure

CAS No. : 2250313-14-3

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Based on 1 publication(s) in Google Scholar

Influenza A virus-IN-1 Related Antibodies

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Description

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA[1].

IC50 & Target

IC50: 3.11 μM (A/Puerto Rico/8/34 (H1N1)), 3.58 μM (A/FM-1/1/47 (H1N1)), 5.26 μM (A/Aichi/2/68 (H3N2)), 6.48 μM (A/PR/8/34 (H1N1) with NA-H274Y) and 7.13 μM (The influenza A virus 690 (H3))
In Vitro

Influenza A virus-IN-1 (compound 5-2; 5-40 μM; 24 hours; MDCK cells) treatment significantly decreases the yields of influenza viral NP in a dose-dependent manner. And the expression level of NP protein could also be restrained in a dose-dependent manner[1].
Influenza A virus-IN-1 (compound 5-2) treatment reduces influenza HA mRNA expression at all three time points[1].
Influenza A virus-IN-1 (compound 5-2) could efficiently inhibit replication of IAV and suppress the production of the NDAPH oxidase NOX1 in MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: IAV-infected MDCK cells
Concentration: 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 hours
Result: Significantly decreased the yields of influenza viral NP in a dose-dependent manner.
Molecular Weight

534.45

Formula

C27H20F6N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(NC2=CC=C(C(F)(F)F)C=C2)C(N(C3=CC=C(C(F)(F)F)C=C3)C1C4=CC=CC=C4)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (187.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8711 mL 9.3554 mL 18.7108 mL
5 mM 0.3742 mL 1.8711 mL 3.7422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8711 mL 9.3554 mL 18.7108 mL 46.7771 mL
5 mM 0.3742 mL 1.8711 mL 3.7422 mL 9.3554 mL
10 mM 0.1871 mL 0.9355 mL 1.8711 mL 4.6777 mL
15 mM 0.1247 mL 0.6237 mL 1.2474 mL 3.1185 mL
20 mM 0.0936 mL 0.4678 mL 0.9355 mL 2.3389 mL
25 mM 0.0748 mL 0.3742 mL 0.7484 mL 1.8711 mL
30 mM 0.0624 mL 0.3118 mL 0.6237 mL 1.5592 mL
40 mM 0.0468 mL 0.2339 mL 0.4678 mL 1.1694 mL
50 mM 0.0374 mL 0.1871 mL 0.3742 mL 0.9355 mL
60 mM 0.0312 mL 0.1559 mL 0.3118 mL 0.7796 mL
80 mM 0.0234 mL 0.1169 mL 0.2339 mL 0.5847 mL
100 mM 0.0187 mL 0.0936 mL 0.1871 mL 0.4678 mL
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Influenza A virus-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-12250313-14-3Influenza VirusDihydropyrrolidonesinfluenza-AvirusH1N1H3N2replication NDAPHNOX1IFN-βMxAInhibitorinhibitorinhibit

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