Influenza A virus-IN-1
Based on 1 Customer Validation
Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 2250313-14-3
- Formula: C27H20F6N2O3
- Molecular Weight:534.45
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.11 μM (A/Puerto Rico/8/34 (H1N1)), 3.58 μM (A/FM-1/1/47 (H1N1)), 5.26 μM (A/Aichi/2/68 (H3N2)), 6.48 μM (A/PR/8/34 (H1N1) with NA-H274Y) and 7.13 μM (The influenza A virus 690 (H3))
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Cell Line
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Type | Value | Description | References |
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| A549 | CC50 |
>400 μM
Compound: 2
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 32408213] |
| MDCK | CC50 |
>400 μM
Compound: 2
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Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 32408213] |
Influenza A virus-IN-1 (compound 5-2; 5-40 μM; 24 hours; MDCK cells) treatment significantly decreases the yields of influenza viral NP in a dose-dependent manner. And the expression level of NP protein could also be restrained in a dose-dependent manner[1].
Influenza A virus-IN-1 (compound 5-2) treatment reduces influenza HA mRNA expression at all three time points[1].
Influenza A virus-IN-1 (compound 5-2) could efficiently inhibit replication of IAV and suppress the production of the NDAPH oxidase NOX1 in MDCK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IAV-infected MDCK cells
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Concentration:5 μM, 10 μM, 20 μM, 40 μM
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Incubation Time:24 hours
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Result:Significantly decreased the yields of influenza viral NP in a dose-dependent manner.
Chemical Information
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CAS No. 2250313-14-3
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Appearance Solid
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Molecular Weight 534.45
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Formula C27H20F6N2O3
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Color White to off-white
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SMILES
O=C(C1=C(NC2=CC=C(C(F)(F)F)C=C2)C(N(C3=CC=C(C(F)(F)F)C=C3)C1C4=CC=CC=C4)=O)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (187.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8711 mL | 9.3554 mL | 18.7108 mL | 46.7771 mL |
| 5 mM | 0.3742 mL | 1.8711 mL | 3.7422 mL | 9.3554 mL | |
| 10 mM | 0.1871 mL | 0.9355 mL | 1.8711 mL | 4.6777 mL | |
| 15 mM | 0.1247 mL | 0.6237 mL | 1.2474 mL | 3.1185 mL | |
| 20 mM | 0.0936 mL | 0.4678 mL | 0.9355 mL | 2.3389 mL | |
| 25 mM | 0.0748 mL | 0.3742 mL | 0.7484 mL | 1.8711 mL | |
| 30 mM | 0.0624 mL | 0.3118 mL | 0.6237 mL | 1.5592 mL | |
| 40 mM | 0.0468 mL | 0.2339 mL | 0.4678 mL | 1.1694 mL | |
| 50 mM | 0.0374 mL | 0.1871 mL | 0.3742 mL | 0.9355 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7796 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2339 mL | 0.5847 mL | |
| 100 mM | 0.0187 mL | 0.0936 mL | 0.1871 mL | 0.4678 mL |
Influenza A virus-IN-1 Related Classifications
HY-131179 Related Classifications
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