1. Anti-infection
  2. Influenza Virus
  3. Influenza A virus-IN-1

Influenza A virus-IN-1 

Cat. No.: HY-131179
Handling Instructions

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA.

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Influenza A virus-IN-1 Chemical Structure

Influenza A virus-IN-1 Chemical Structure

CAS No. : 2250313-14-3

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Description

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA[1].

IC50 & Target

IC50: 3.11 μM (A/Puerto Rico/8/34 (H1N1)), 3.58 μM (A/FM-1/1/47 (H1N1)), 5.26 μM (A/Aichi/2/68 (H3N2)), 6.48 μM (A/PR/8/34 (H1N1) with NA-H274Y) and 7.13 μM (The influenza A virus 690 (H3))

In Vitro

Influenza A virus-IN-1 (compound 5-2; 5-40 μM; 24 hours; MDCK cells) treatment significantly decreases the yields of influenza viral NP in a dose-dependent manner. And the expression level of NP protein could also be restrained in a dose-dependent manner[1].
Influenza A virus-IN-1 (compound 5-2) treatment reduces influenza HA mRNA expression at all three time points[1].
Influenza A virus-IN-1 (compound 5-2) could efficiently inhibit replication of IAV and suppress the production of the NDAPH oxidase NOX1 in MDCK cells[1].

Western Blot Analysis[1]

Cell Line: IAV-infected MDCK cells
Concentration: 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 hours
Result: Significantly decreased the yields of influenza viral NP in a dose-dependent manner.
Molecular Weight

534.45

Formula

C₂₇H₂₀F₆N₂O₃

CAS No.

2250313-14-3

SMILES

O=C(C1=C(NC2=CC=C(C(F)(F)F)C=C2)C(N(C3=CC=C(C(F)(F)F)C=C3)C1C4=CC=CC=C4)=O)OCC

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Influenza A virus-IN-1Influenza VirusDihydropyrrolidonesinfluenza-AvirusH1N1H3N2replication NDAPHNOX1IFN-βMxAInhibitorinhibitorinhibit

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Influenza A virus-IN-1
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