2. Anti-infection
  3. RSV
  4. ADI-14448

ADI-14448 is a RSV prefusion fusion glycoprotein inhibitor and HMPV fusion glycoprotein inhibitor, with a Kd of 3.8 × 10-10 M for RSV preF. ADI-14448 binds to epitope III of RSV preF, thereby blocking viral infection. ADI-14448 neutralizes RSV subtype A and HMPV subtype A1. ADI-14448 can be used in studies related to respiratory syncytial virus infection and metapneumovirus infection.

For research use only. We do not sell to patients.

ADI-14448

ADI-14448 Chemical Structure

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ADI-14448 Related Antibodies

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Description

ADI-14448 is a RSV prefusion fusion glycoprotein inhibitor and HMPV fusion glycoprotein inhibitor, with a Kd of 3.8 × 10-10 M for RSV preF. ADI-14448 binds to epitope III of RSV preF, thereby blocking viral infection. ADI-14448 neutralizes RSV subtype A and HMPV subtype A1. ADI-14448 can be used in studies related to respiratory syncytial virus infection and metapneumovirus infection[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Virus
In Vitro

ADI-14448 binds specifically to pre-fusion RSV F (DS-Cav1) with high affinity, with an apparent Kd of 3.8 × 10-10 M, and does not bind to post-fusion RSV F (F DFP)[1].
ADI-14448 (subjected to serial four-fold dilutions from 1:10 to 1:163,840; pre-incubated with virus for 1 h prior to incubation with HEp-2 cells for 22-24 h) potently neutralizes RSV subtype A (strain A2) in HEp-2 cells, with an IC50 of 0.04 μg/mL[1].
ADI-14448 (serial dilutions; 36 h) potently neutralizes the HMPV A1 sublineage (NL/1/00) in Vero-118 cells, with an IC50 of 0.05 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADI-14448 Related Antibodies
Gene ID

/  [NCBI]

Accession

P03420
Target

HRSV F0/F Protein
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADI-14448 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADI-14448ADI14448ADI 14448RSVRespiratory syncytial virushuman RSV preFRSV preF antigenic site IIIhuman HMPV FHMPV fusion glycoproteinHEp-2 cellshuman metapneumovirus infectionrespiratory syncytial virus infectionprefusion RSV F (DS-Cav1)Vero-118 cellsRSV prefusion fusion glycoproteinInhibitorinhibitorinhibit

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