L-Glutamic acid ammonium

Name: L-Glutamic acid ammonium
Brand: MedChemExpress
SKU: HY-W419700
Rating: 5.0 (12 reviews)

Cat. No.: HY-W419700 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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L-Glutamic acid ammonium is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid ammonium has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid ammonium acts at ionotropic and?metabotropic glutamate receptors.

For research use only. We do not sell to patients.

CAS No. : 7558-63-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of L-Glutamic acid ammonium:

L-Glutamic acid In-stock

12 Publications Citing Use of MCE L-Glutamic acid ammonium

Bio/Physico-chemical Assay

Flow Cytometry

Cell Proliferation/Viability Assay

RT-PCR

Cell Imaging/Staining

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 5:e11194. [Abstract]; L-Glutamic acid (100 µM; 10 min) for activation of spike count. Spontaneous LFP activity is recorded from OPAB that has been pre-treated with Bicuculline and stimulated with L-Glutamic acid. The LFP signal from the activated OPAB is measured (pre), and then the electrical signal is inhibited for 10 min using a cocktail of TTX, CNQX, and AP5 and LFP was recorded again (post).

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jun 7;74(8):240. [Abstract]; Flow cytometry representative image showing the effect of exogenous glutamate (1 mM) on mouse primary T cells.

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Viability of HT22 cells treated with Glutamate at different concentrations (0, 5, 10, 15, 20 and 25 mM) for 24 h (n=5 at each concentration).

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; The relative mRNA expression levels of c-fos in the control, glu (20 mM, 24 h) and lactate groups (n=6 in each group).

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Fluorescence images of TUNEL staining of HT22 cells in the control, glu (20 mM, 24 h) and lactate groups.

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Images of VGLUT1 fluorescence staining in HT22 cells from the control, glu (20 mM, 24 h) and lactate groups.

: L-Glutamic acid ammonium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 18;22(1):178. [Abstract]; PC3 and DU145 cells were treated with 10 μM glutamate for 24 h, after which the protein expression levels were analysed by western blotting. The expression intensity was normalized to that of β-tubulin (right panel).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

L-Glutamic acid (120-1000 mg/dL) ammonium can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus^[3].
L-Glutamic acid (2-20 mM, 24-48 h) ammonium can induce neuroexcitotoxicity in neuroblastoma^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	SH-SY5Y, IMR-32, SK-N-BE(2)
Concentration:	2, 5, 10, 20 mM
Incubation Time:	24 and 48 h
Result:	Reduced cell viability in a dose-dependent manner.

In Vivo

L-Glutamic acid (3 g/kg, subcutaneous injection, single dose) ammonium can promote excitotoxic degeneration of retinal ganglion cells in mice^[1].
L-Glutamic acid (750 mg/kg, intraperitoneal injection, single dose) ammonium can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Crv4 mice model^[1]
Dosage:	3 g/kg
Administration:	s.c., single dose
Result:	Reduced the number of Brn-3a⁺ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.

Animal Model:	CPF-induced rat model^[5]
Dosage:	750 mg/kg
Administration:	i.p., single dose
Result:	Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.

Molecular Weight

164.16

Formula

C₅H₁₂N₂O₄

CAS No.

7558-63-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC[C@H](N)C(O)=O.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (609.16 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0916 mL	30.4581 mL	60.9162 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (246 KB) HNMR (110 KB) MS (192 KB)

Handling Instructions (2659 KB)

References

[1]. Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149. [Content Brief]

[2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. [Content Brief]

[3]. Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132. [Content Brief]

[4]. Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30. [Content Brief]

[5]. Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.0916 mL	30.4581 mL	60.9162 mL	152.2904 mL
	5 mM	1.2183 mL	6.0916 mL	12.1832 mL	30.4581 mL
	10 mM	0.6092 mL	3.0458 mL	6.0916 mL	15.2290 mL
	15 mM	0.4061 mL	2.0305 mL	4.0611 mL	10.1527 mL
	20 mM	0.3046 mL	1.5229 mL	3.0458 mL	7.6145 mL
	25 mM	0.2437 mL	1.2183 mL	2.4366 mL	6.0916 mL
	30 mM	0.2031 mL	1.0153 mL	2.0305 mL	5.0763 mL
	40 mM	0.1523 mL	0.7615 mL	1.5229 mL	3.8073 mL
	50 mM	0.1218 mL	0.6092 mL	1.2183 mL	3.0458 mL
	60 mM	0.1015 mL	0.5076 mL	1.0153 mL	2.5382 mL
	80 mM	0.0761 mL	0.3807 mL	0.7615 mL	1.9036 mL
	100 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.5229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.