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  2. Smilagenin

Smilagenin 

Cat. No.: HY-106353 Purity: >98.0%
Handling Instructions

Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.

For research use only. We do not sell to patients.

Smilagenin Chemical Structure

Smilagenin Chemical Structure

CAS No. : 126-18-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].

In Vitro

Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3].
Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2].

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Elevated the SH-SY5Y cell viability.

RT-PCR[2]

Cell Line: SH-SY5Y cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased GDNF and BDNF transcription.
In Vivo

Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2].

Animal Model: MPTP/probenecid-induced mouse model[2]
Dosage: 10 or 26 mg/kg
Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days
Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.
Molecular Weight

416.64

Formula

C₂₇H₄₄O₃

CAS No.

126-18-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 10 mg/mL (24.00 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL
10 mM 0.2400 mL 1.2001 mL 2.4002 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Smilagenin
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HY-106353
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