2. GPCR/G Protein Metabolic Enzyme/Protease Neuronal Signaling
  3. mAChR Endogenous Metabolite
  4. Smilagenin

Smilagenin 

Cat. No.: HY-106353 Purity: ≥98.0%
COA Handling Instructions

Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.

For research use only. We do not sell to patients.

Smilagenin Chemical Structure

Smilagenin Chemical Structure

CAS No. : 126-18-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 88 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 120 In-stock
50 mg USD 350 In-stock
100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Smilagenin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Smilagenin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].

IC50 & Target

mAChR1

 

In Vitro

Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3].
Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Smilagenin Related Antibodies

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Elevated the SH-SY5Y cell viability.

RT-PCR[2]

Cell Line: SH-SY5Y cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased GDNF and BDNF transcription.
In Vivo

Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP/probenecid-induced mouse model[2]
Dosage: 10 or 26 mg/kg
Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days
Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.
Molecular Weight

416.64

Appearance

Solid

Formula

C27H44O3
CAS No.
SMILES

C[C@@H]1[C@@]2(CC[C@@H](C)CO2)O[C@]3([H])[C@@]1([H])[C@@]4([C@@]([C@@]5([H])[C@]([C@@]6([C@](C[C@@H](O)CC6)([H])CC5)C)([H])CC4)([H])C3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 10 mg/mL (24.00 mM)

DMSO : 5 mg/mL (12.00 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL
10 mM 0.2400 mL 1.2001 mL 2.4002 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Smilagenin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Smilagenin126-18-1mAChREndogenous MetaboliteMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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