Bodilisant 

Bodilisant is a histamine H3 receptor (hH3R) ligand and imaging/labeling agent, with a K_i value of 6.51 nM for hH3R. Bodilisant binds to hH3R to produce strong green fluorescence, localizes to the extracellular membrane without internalization, and generates clear, displaceable fluorescent labeling of hH3R in native human brain tissues. Bodilisant serves as a pharmacological tool to visualize the distribution of hH3R via fluorescence confocal laser scanning microscopy^[1].

Bodilisant (10 mM) is a strong green fluorescent compound with a quantum yield of 0.92, a maximum absorption wavelength of 468 nm, and maximum emission wavelengths of 494 nm and 563 nm. It exhibits stable luminescence in neutral aqueous buffers^[1].
Bodilisant (8 nM) specifically labels human histamine H₃ receptors on the plasma membrane of HEK-293 cells overexpressing hH₃R, and produces strong green fluorescence^[1].
Bodilisant (1 μM) specifically labels native human histamine H₃ receptors in human brain tissues, including globus pallidus sections^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

465.39

C₂₇H₃₄BF₂N₃O

1416130-06-7

Solid

Orange to red

[F-][B+3]1([N]2=C(C)C=C(C)C2=C(C3=C(C)C=C(C)[N-]31)C4=CC=C(C=C4)OCCCN5CCCCC5)[F-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Tomasch M, et al. Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand. ACS Med Chem Lett. 2012;4(2):269-273. Published 2012 Dec 12.  [Content Brief]