Naftopidil hydrochloride
Based on 1 publication(s) in Google Scholar
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 1164469-60-6
- Formula: C24H29ClN2O3
- Molecular Weight:428.95
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Naftopidil hydrochloride
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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Alpha-1A adrenergic receptor 3.7 nM (Ki) |
Alpha-1B adrenergic receptor 20 nM (Ki) |
Alpha-1D adrenergic receptor 1.2 nM (Ki) |
Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PCa cells, PrSC
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Concentration:10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
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Incubation Time:3 days
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Result:Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.
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Cell Line:PCa cells, PrSC
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Concentration:50 μM (E9 cells), 25 μM (PrSC)
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Incubation Time:48 hours
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Result:Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
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Dosage:10 mg/kg
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Administration:Oral administration, daily, for 28 days
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Result:Decreased tumor weights.
Chemical Information
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CAS No. 1164469-60-6
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Appearance Solid
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Molecular Weight 428.95
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Formula C24H29ClN2O3
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Color White to off-white
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SMILES
[H]Cl.OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34
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Synonyms
KT-611 hydrochloride; BM-15275 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency. [Abstract]2025 May:140:156621. PMID: 40088741
Solvent & Solubility
DMSO : 25 mg/mL (58.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54. [Content Brief]
[2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3313 mL | 11.6564 mL | 23.3127 mL | 58.2818 mL |
| 5 mM | 0.4663 mL | 2.3313 mL | 4.6625 mL | 11.6564 mL | |
| 10 mM | 0.2331 mL | 1.1656 mL | 2.3313 mL | 5.8282 mL | |
| 15 mM | 0.1554 mL | 0.7771 mL | 1.5542 mL | 3.8855 mL | |
| 20 mM | 0.1166 mL | 0.5828 mL | 1.1656 mL | 2.9141 mL | |
| 25 mM | 0.0933 mL | 0.4663 mL | 0.9325 mL | 2.3313 mL | |
| 30 mM | 0.0777 mL | 0.3885 mL | 0.7771 mL | 1.9427 mL | |
| 40 mM | 0.0583 mL | 0.2914 mL | 0.5828 mL | 1.4570 mL | |
| 50 mM | 0.0466 mL | 0.2331 mL | 0.4663 mL | 1.1656 mL |
Naftopidil hydrochloride Related Classifications
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