Naftopidil dihydrochloride
Based on 1 publication(s) in Google Scholar
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.
For research use only. We do not sell to patients.
- CAS No.: 57149-08-3
- Formula: C24H30Cl2N2O3
- Molecular Weight:465.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Naftopidil dihydrochloride
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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Alpha-1A adrenergic receptor 3.7 nM (Ki) |
Alpha-1B adrenergic receptor 20 nM (Ki) |
Alpha-1D adrenergic receptor 1.2 (Ki) |
Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PCa cells, PrSC
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Concentration:10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
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Incubation Time:3 days
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Result:Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.
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Cell Line:PCa cells, PrSC
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Concentration:50 μM (E9 cells), 25 μM (PrSC)
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Incubation Time:48 hours
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Result:Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
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Dosage:10 mg/kg
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Administration:Oral administration, daily, for 28 days
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Result:Decreased tumor weights.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 57149-08-3
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Molecular Weight 465.41
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Formula C24H30Cl2N2O3
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SMILES
[H]Cl.[H]Cl.OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34
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Synonyms
KT-611 dihydrochloride; BM-15275 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency. [Abstract]2025 May:140:156621. PMID: 40088741
Purity & Documentation
References
[1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54. [Content Brief]
[2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Naftopidil dihydrochloride Related Classifications
HY-B0391A Related Classifications
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