1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Naftopidil dihydrochloride

Naftopidil dihydrochloride (Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Cat. No.: HY-B0391A
Handling Instructions

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.

For research use only. We do not sell to patients.

Naftopidil dihydrochloride Chemical Structure

Naftopidil dihydrochloride Chemical Structure

CAS No. : 57149-08-3

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Description

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].

IC50 & Target

α1-adrenoceptor[1]

In Vitro

Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[1].
Naftopidil dihydrochloride (10 μM for PCa cells; 0.1-10 Μm for PrSC) shows growth inhibitory effects on PrSC and PCa cells[1].
Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[1].

Cell Proliferation Assay[1]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells, PrSC in dose-dependent manners.

Western Blot Analysis[1]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
In Vivo

Naftopidil dihydrochloride (10 mg/kg; p.o; daily, for 28 days) decreases microvessel density (MVD) in E9 + PrSC tumors mice model[1].
Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1]

Animal Model: Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decrease tumor weights.
Molecular Weight

465.41

Formula

C₂₄H₃₀Cl₂N₂O₃

CAS No.

57149-08-3

SMILES

[H]Cl.[H]Cl.OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NaftopidilKT-611BM-15275KT611KT 611BM15275BM 15275Adrenergic ReceptorBeta ReceptorprostatehyperplasiacanineprostaticpressureInhibitorinhibitorinhibit

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Naftopidil dihydrochloride
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