1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. TC-2559 difumarate

TC-2559 difumarate 

Cat. No.: HY-136207
Handling Instructions

TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect.

For research use only. We do not sell to patients.

TC-2559 difumarate Chemical Structure

TC-2559 difumarate Chemical Structure

CAS No. : 2454492-41-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].

In Vivo

TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2].
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male mice (body weight 15-30 g) (formalin test)[2]
Dosage: 1, 3, 10 mg/kg
Administration: I.p.
Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses.
Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2]
Dosage: 0.3, 1, 3 mg/kg
Administration: I.p.
Result: Significantly reversed CCI induced the paw withdrawal threshold decreases.
Molecular Weight

438.43

Formula

C₂₀H₂₆N₂O₉

CAS No.

2454492-41-0

SMILES

CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TC-2559 difumaratenAChRNicotinic acetylcholine receptorsnociceptiveresponsespainCNS-selectiveoralInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TC-2559 difumarate
Cat. No.:
HY-136207
Quantity:
MCE Japan Authorized Agent: