TC-2559 difumarate
Based on 1 Customer Validation
TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect.
For research use only. We do not sell to patients.
- Purity: 98.4%
- CAS No.: 2454492-41-0
- Formula: C20H26N2O9
- Molecular Weight:438.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male mice (body weight 15-30 g) (formalin test)[2]
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Dosage:1, 3, 10 mg/kg
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Administration:I.p.
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Result:Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses.
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Animal Model:Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2]
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Dosage:0.3, 1, 3 mg/kg
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Administration:I.p.
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Result:Significantly reversed CCI induced the paw withdrawal threshold decreases.
Chemical Information
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CAS No. 2454492-41-0
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Appearance Solid
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Molecular Weight 438.43
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Formula C20H26N2O9
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Color White to off-white
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SMILES
CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 43.84 mg/mL (99.99 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. [Content Brief]
[2]. Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2809 mL | 11.4043 mL | 22.8087 mL | 57.0216 mL |
| 5 mM | 0.4562 mL | 2.2809 mL | 4.5617 mL | 11.4043 mL | |
| 10 mM | 0.2281 mL | 1.1404 mL | 2.2809 mL | 5.7022 mL | |
| 15 mM | 0.1521 mL | 0.7603 mL | 1.5206 mL | 3.8014 mL | |
| 20 mM | 0.1140 mL | 0.5702 mL | 1.1404 mL | 2.8511 mL | |
| 25 mM | 0.0912 mL | 0.4562 mL | 0.9123 mL | 2.2809 mL | |
| 30 mM | 0.0760 mL | 0.3801 mL | 0.7603 mL | 1.9007 mL | |
| 40 mM | 0.0570 mL | 0.2851 mL | 0.5702 mL | 1.4255 mL | |
| 50 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1404 mL | |
| 60 mM | 0.0380 mL | 0.1901 mL | 0.3801 mL | 0.9504 mL | |
| 80 mM | 0.0285 mL | 0.1426 mL | 0.2851 mL | 0.7128 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TC-2559 difumarate Related Classifications
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