2454492-41-0
2454492-41-0
Chemical Structure
TC-2559 difumarate
- CAS No.: 2454492-41-0
- Formula:C20H26N2O9
- Molecular Weight:438.43
IUPAC Name: (E)-4-(5-ethoxypyridin-3-yl)-N-methylbut-3-en-1-amine difumarate
InChIKey: GEWVPSJQGJBDLM-MYBAKCFCSA-N
SMILES: CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O
Biological Activity: TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC-2559 difumarate | 98.4% | TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect. | ||||||||||||||||||||
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References
- [1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. [Content Brief]
- [2]. Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4. [Content Brief]
Keywords
