2454492-41-0
2454492-41-0
Chemical Structure
TC-2559 difumarate
- CAS No.: 2454492-41-0
- Formula:C20H26N2O9
- Molecular Weight:438.43
IUPAC Name: (E)-4-(5-ethoxypyridin-3-yl)-N-methylbut-3-en-1-amine difumarate
InChIKey: GEWVPSJQGJBDLM-MYBAKCFCSA-N
SMILES: CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O
Biological Activity: TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC-2559 difumarate | 98.4% | TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.85
HY-107667TC-2559 fumarate -
Similarity Score 0.70
HY-171807TC-2559 free base -
Similarity Score 0.65
HY-13225DRivanicline fumarate -
Similarity Score 0.58
HY-13225Rivanicline oxalate -
Similarity Score 0.55
HY-10063Ispronicline -
Similarity Score 0.53
HY-W1129483,3',3''-(Benzene-1,3,5-triyl)triacrylicacid -
Similarity Score 0.51
HY-13225ARivanicline -
Similarity Score 0.51
HY-13225E(E/Z)-Rivanicline -
Similarity Score 0.50
HY-W243996(2E,2'E,2''E)-3,3',3''-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacrylic acid -
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References
- [1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. [Content Brief]
- [2]. Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4. [Content Brief]
