1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. NGB 2904 hydrochloride

NGB 2904 hydrochloride 

Cat. No.: HY-12697A
Handling Instructions

NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior.

For research use only. We do not sell to patients.

NGB 2904 hydrochloride Chemical Structure

NGB 2904 hydrochloride Chemical Structure

CAS No. : 189061-11-8

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Description

NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior[1][2].

IC50 & Target[1]

D3 Receptor

1.4 (Ki)

In Vitro

NGB 2904 antagonizes Quinpirole (100 nM)-stimulated mitogenesis, with an IC50 of 5.0 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NGB 2904 (0.1-5 mg/kg; i.p. 30 min prior to test) attenuates Cocaine's rewarding effects as assessed by PR self-administration, BSR, and Cocaine-triggered reinstatement of Cocaine-seeking behavior in rats[2].
NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naïve male Long-Evans rats (250-300g)[2]
Dosage: 0.1, 1, 5 mg/kg
Administration: I.p. 30 min prior to test
Result: Lowered the break-point for Cocaine (0.5 mg/kg; infusion) self-administration under progressive-ratio (PR) reinforcement.
Inhibited the Cocaine (2 mg/kg; i.p.)-enhanced electrical brain stimulation reward (BSR).
Inhibited Cocaine (10 mg/kg; i.p.)-triggered reinstatement of extinguished drug-seeking behavior.
Molecular Weight

530.92

Formula

C₂₈H₃₀Cl₃N₃O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NGB 2904 hydrochloride
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HY-12697A
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