1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. NGB 2904

NGB 2904 

Cat. No.: HY-12697 Purity: 99.08%
Handling Instructions

NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction.

For research use only. We do not sell to patients.

NGB 2904 Chemical Structure

NGB 2904 Chemical Structure

CAS No. : 189060-98-8

Size Price Stock Quantity
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 340 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction[1].

IC50 & Target[1]

D3 Receptor

 

In Vivo

NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration[1].
NGB 2904 (0~10 mg/kg; i.p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long–Evans rats (250–300 g)[1]
Dosage: 0.1~5 mg/kg
Administration: I.p.;
Result: Significantly lowered the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibited cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration.
Molecular Weight

494.46

Formula

C₂₈H₂₉Cl₂N₃O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 4.55 mg/mL (9.20 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0224 mL 10.1120 mL 20.2241 mL
5 mM 0.4045 mL 2.0224 mL 4.0448 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
NGB 2904
Cat. No.:
HY-12697
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