189060-98-8
Chemical Structure
NGB 2904
- CAS No.: 189060-98-8
- Formula:C28H29Cl2N3O
- Molecular Weight:494.46
IUPAC Name: N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide
InChIKey: YJPWVCIGSHWNON-UHFFFAOYSA-N
SMILES: O=C(C1=CC(CC2=C3C=CC=C2)=C3C=C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4
Biological Activity: NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis[1][2].
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NGB 2904 | 99.76% | NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis. | ||||||||||||||||||||
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Similarity Score 0.99
HY-12697ANGB 2904 hydrochloride -
Similarity Score 0.70
HY-119277CJB-090 dihydrochloride -
Similarity Score 0.67
HY-116020FAUC 365 -
Similarity Score 0.62
HY-106660RBP 897 hydrochloride (Standard) -
Similarity Score 0.62
HY-114085BP 897 -
Similarity Score 0.62
HY-174307Dopamine D3 receptor ligand-6 -
Similarity Score 0.61
HY-103408PG01037 dihydrochloride -
Similarity Score 0.59
HY-101382GR 103691 -
Similarity Score 0.59
HY-115968Dopamine D3 receptor ligand-4 -
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References
- [1]. Yuan J, et, al. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8. [Content Brief]
- [2]. Xi ZX, et al. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology. 2006;31(7):1393-1405. [Content Brief]
