1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. BP 897

BP 897 

Cat. No.: HY-114085
Handling Instructions

BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior.

For research use only. We do not sell to patients.

BP 897 Chemical Structure

BP 897 Chemical Structure

CAS No. : 192384-87-5

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Description

BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior[1].

In Vitro

BP 897 also displays low affinities at D1 and D4 receptors (Ki=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (Ki=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki=84 and 345 nM, respectively), and negligible affinities (Ki>1 μM) atmuscarinic, histamine and opiate receptors[1].
In NG 108-15 cells expressing the human D3 receptor, BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1 nM. BP 897 activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 also partially antagonized the response induced by quinpirole (10 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BP 897 (0.05, 0.5, 1 mg/kg; i.p.; 30 min before the session) reduces cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Listar hooded rats[1]
Dosage: 0.05, 0.5, 1 mg/kg
Administration: i.p.; 30 min before the session
Result: Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
Molecular Weight

417.54

Formula

C₂₆H₃₁N₃O₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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BP 897
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HY-114085
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