2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. BP 897 hydrochloride

BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM).

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BP 897 hydrochloride Chemical Structure

BP 897 hydrochloride Chemical Structure

CAS No. : 314776-92-6

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Based on 1 publication(s) in Google Scholar

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BP 897 hydrochloride Related Antibodies

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Description

BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1].

IC50 & Target

D2 Receptor

 

D3 Receptor

 

In Vitro

BP 897 hydrochloride also displays low affinities at D1 and D4 receptors (Ki=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (Ki=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki=84 and 345 nM, respectively), and negligible affinities (Ki>1 μM) atmuscarinic, histamine and opiate receptors[1].
In NG 108-15 cells expressing the human D3 receptor, BP 897 hydrochloride inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1 nM. BP 897 hydrochloride activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 hydrochloride also partially antagonized the response induced by quinpirole (10 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BP 897 hydrochloride Related Antibodies
In Vivo

BP 897 hydrochloride binds to D2-receptor in mouse striatum with an ED50 of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Listar hooded rats[1]
Dosage: 0.05, 0.5, 1 mg/kg
Administration: i.p.; 30 min before the session
Result: Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
Molecular Weight

454.00

Formula

C26H32ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(N2CCN(CCCCNC(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)C=CC=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2026 mL 11.0132 mL 22.0264 mL
5 mM 0.4405 mL 2.2026 mL 4.4053 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2026 mL 11.0132 mL 22.0264 mL 55.0661 mL
5 mM 0.4405 mL 2.2026 mL 4.4053 mL 11.0132 mL
10 mM 0.2203 mL 1.1013 mL 2.2026 mL 5.5066 mL
15 mM 0.1468 mL 0.7342 mL 1.4684 mL 3.6711 mL
20 mM 0.1101 mL 0.5507 mL 1.1013 mL 2.7533 mL
25 mM 0.0881 mL 0.4405 mL 0.8811 mL 2.2026 mL
30 mM 0.0734 mL 0.3671 mL 0.7342 mL 1.8355 mL
40 mM 0.0551 mL 0.2753 mL 0.5507 mL 1.3767 mL
50 mM 0.0441 mL 0.2203 mL 0.4405 mL 1.1013 mL
60 mM 0.0367 mL 0.1836 mL 0.3671 mL 0.9178 mL
80 mM 0.0275 mL 0.1377 mL 0.2753 mL 0.6883 mL
100 mM 0.0220 mL 0.1101 mL 0.2203 mL 0.5507 mL
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BP 897 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BP 897314776-92-6BP897BP-897Dopamine Receptordrug-seekingbehaviourmotivationaladdictionrewardingstimuliInhibitorinhibitorinhibit

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