1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. BP 897

BP 897 

Cat. No.: HY-106660
Handling Instructions

BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 µM, respectively).

For research use only. We do not sell to patients.

BP 897 Chemical Structure

BP 897 Chemical Structure

CAS No. : 314776-92-6

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Description

BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 µM, respectively).

IC50 & Target

Ki: 0.92 nM (D3 receptor), 61 nM (D2 receptor), 0.3 µM (D4 receptor), 3 µM (D1 receptor)[1].

In Vitro

BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with a Ki of 0.92 nM for D3 receptor, a 70 times lower affinity at the D2 receptor (Ki, 61 nM), and shows low affinities at D1 and D4 receptors (Ki = 3 and 0.3 µM, respectively). BP 897 also weakly binds to α1 and α2 adrenergic receptors (Ki = 60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki = 84 and 345 nM, respectively), and has negligible affinities (Ki > 1 µM) at muscarinic, histamine and opiate receptors. BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1.0 ± 0.3 nM, and increases mitogenesis, another D3-receptor-mediated response (EC50 = 3 ± 1 nM) in NG 108-15 cells expressing the human D3 receptor. However, BP 897 (1 µM) does not inhibit cyclic AMP accumulation or trigger mitogenesis in cells expressing the D2 receptor[1].

In Vivo

BP 897 binds to D2-receptor in mouse striatum with an ED50 of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg. BP 897 (0, 0.05, 0.5, 1 mg/kg) inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects[1].

Molecular Weight

454.00

Formula

C₂₆H₃₂ClN₃O₂

CAS No.

314776-92-6

SMILES

COC1=C(N2CCN(CCCCNC(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)C=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BP 897
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HY-106660
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