BP 897 hydrochloride
Based on 1 Customer Validation
BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM).
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 314776-92-6
- Formula: C26H32ClN3O2
- Molecular Weight:454.00
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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D2 Receptor |
D3 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | CC50 |
30.03 μM
Compound: BP-897
|
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
|
10.21203/rs.3.rs-23951/v1 |
| Caco-2 | IC50 |
18.95 μM
Compound: BP-897
|
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
|
10.21203/rs.3.rs-23951/v1 |
| CHO | EC50 |
2.7 nM
Compound: BP897
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Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor
Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor
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[PMID: 15916420] |
| COS-7 | IC50 |
0.41 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
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10.1007/s00044-004-0006-x |
| COS-7 | IC50 |
0.72 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
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10.1007/s00044-004-0006-x |
| COS-7 | IC50 |
1.02 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
|
10.1007/s00044-004-0006-x |
| COS-7 | IC50 |
24.2 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
|
10.1007/s00044-004-0006-x |
| COS-7 | IC50 |
27.5 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
|
10.1007/s00044-004-0006-x |
| COS-7 | IC50 |
28.3 nM
Compound: BP897
|
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting
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10.1007/s00044-004-0006-x |
| U2OS | IC50 |
13 nM
Compound: 6, BP 897
|
Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recruitment
Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recruitment
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[PMID: 24848155] |
| U2OS | ED50 |
>100000 nM
Compound: 6, BP 897
|
Agonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment
Agonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment
|
[PMID: 24848155] |
BP 897 hydrochloride also displays low affinities at D1 and D4 receptors (Ki=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (Ki=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki=84 and 345 nM, respectively), and negligible affinities (Ki>1 μM) atmuscarinic, histamine and opiate receptors[1].
In NG 108-15 cells expressing the human D3 receptor, BP 897 hydrochloride inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1 nM. BP 897 hydrochloride activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 hydrochloride also partially antagonized the response induced by quinpirole (10 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Listar hooded rats[1]
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Dosage:0.05, 0.5, 1 mg/kg
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Administration:i.p.; 30 min before the session
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Result:Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
Chemical Information
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CAS No. 314776-92-6
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Appearance Solid
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Molecular Weight 454.00
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Formula C26H32ClN3O2
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Color White to off-white
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SMILES
COC1=C(N2CCN(CCCCNC(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)C=CC=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (275.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2026 mL | 11.0132 mL | 22.0264 mL | 55.0661 mL |
| 5 mM | 0.4405 mL | 2.2026 mL | 4.4053 mL | 11.0132 mL | |
| 10 mM | 0.2203 mL | 1.1013 mL | 2.2026 mL | 5.5066 mL | |
| 15 mM | 0.1468 mL | 0.7342 mL | 1.4684 mL | 3.6711 mL | |
| 20 mM | 0.1101 mL | 0.5507 mL | 1.1013 mL | 2.7533 mL | |
| 25 mM | 0.0881 mL | 0.4405 mL | 0.8811 mL | 2.2026 mL | |
| 30 mM | 0.0734 mL | 0.3671 mL | 0.7342 mL | 1.8355 mL | |
| 40 mM | 0.0551 mL | 0.2753 mL | 0.5507 mL | 1.3767 mL | |
| 50 mM | 0.0441 mL | 0.2203 mL | 0.4405 mL | 1.1013 mL | |
| 60 mM | 0.0367 mL | 0.1836 mL | 0.3671 mL | 0.9178 mL | |
| 80 mM | 0.0275 mL | 0.1377 mL | 0.2753 mL | 0.6883 mL | |
| 100 mM | 0.0220 mL | 0.1101 mL | 0.2203 mL | 0.5507 mL |
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