2. PI3K/Akt/mTOR Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Akt Microtubule/Tubulin Apoptosis
  4. Tubulin/AKT1-IN-1

Tubulin/AKT1-IN-1 (Compound D1-1) is an inhibitor of tubulin polymerization and AKT pathway activation. Tubulin/AKT1-IN-1 significantly inhibits the proliferation and metastasis of H1975 cells and slightly induced their apoptosis and can be used for non-small-cell lung cancer (NSCLC) research .

For research use only. We do not sell to patients.

Tubulin/AKT1-IN-1

Tubulin/AKT1-IN-1 Chemical Structure

CAS No. : 2988927-63-3

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Tubulin/AKT1-IN-1 Related Antibodies

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Description

Tubulin/AKT1-IN-1 (Compound D1-1) is an inhibitor of tubulin polymerization and AKT pathway activation. Tubulin/AKT1-IN-1 significantly inhibits the proliferation and metastasis of H1975 cells and slightly induced their apoptosis and can be used for non-small-cell lung cancer (NSCLC) research [1].

Cellular Effect
Cell Line Type Value Description References
BEAS-2B IC50
95.66 μM
Compound: D1-1
Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
HCT-8 IC50
0.16 μM
Compound: D1-1
Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
HT-29 IC50
0.44 μM
Compound: D1-1
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
MCF-10A IC50
> 100 μM
Compound: D1-1
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
MCF7 IC50
1.82 μM
Compound: D1-1
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
MDA-MB-231 IC50
2.63 μM
Compound: D1-1
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
NCI-H1299 IC50
0.81 μM
Compound: D1-1
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
NCI-H1975 IC50
0.1 μM
Compound: D1-1
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
[PMID: 37395092]
Molecular Weight

716.13

Formula

C38H34ClNO11
CAS No.
SMILES

COC1=C(C=C(C=C1OC)[C@@H]2C3=C([C@@H]([C@@H](CO4)[C@@H]2C4=O)OC(CC5=CC=C(NC(COC6=CC=CC(Cl)=C6)=O)C=C5)=O)C=C7OCOC7=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin/AKT1-IN-1 Related Classifications

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/AKT1-IN-12988927-63-3AktMicrotubule/TubulinApoptosisPKBProtein kinase BCancernon-small-cell lung cancer (NSCLC)H1975 cellstubulin polymerizationactivator of AKTInhibitorinhibitorinhibit

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