Milameline hydrochloride
Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease.
For research use only. We do not sell to patients.
- CAS No.: 139886-04-7
- Formula: C8H15ClN2O
- Molecular Weight:190.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR1 1.3 μM (IC50) |
mAChR2 1.1 μM (IC50) |
mAChR3 1.5 μM (IC50) |
mAChR4 1.9 μM (IC50) |
Milameline hydrochloride increases soluble APP (sAPP) secretion in CHO cells transfected with human M1 or M3 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Milameline (0.02- > 0.1 mg/kg, p.o.) hydrochloride effectively reverses scopolamine-induced working memory impairment in rats at low doses (0.02-0.1 mg/kg), but the effect is reduced at high doses (> 0.1 mg/kg)[1].
Milameline hydrochloride increases cerebral blood flow in rats, and its distribution in the brain is consistent with the areas where the cholinergic system is enriched[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139886-04-7
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Molecular Weight 190.67
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Formula C8H15ClN2O
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SMILES
CO/N=C/C1=CCCN(C)C1.Cl
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Synonyms
CI 979 hydrochloride; RU 35926 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Milameline hydrochloride Related Classifications
HY-107650 Related Classifications
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