139886-04-7
Chemical Structure
Milameline hydrochloride
Synonym(s): CI 979 hydrochloride; RU 35926 hydrochloride
- CAS No.: 139886-04-7
- Formula:C8H15ClN2O
- Molecular Weight:190.67
IUPAC Name: (E)-1-methyl-1,2,5,6-tetrahydropyridine-3-carbaldehyde O-methyl oxime hydrochloride
InChIKey: WEBMRZODPLSRKR-MLBSPLJJSA-N
SMILES: CO/N=C/C1=CCCN(C)C1.Cl
Biological Activity: Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease[1].
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Milameline hydrochloride | Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease. | |||||||||||||||||||||
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Keywords
