1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. CypD-IN-3

CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.

For research use only. We do not sell to patients.

CypD-IN-3 Chemical Structure

CypD-IN-3 Chemical Structure

CAS No. : 2651994-75-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All Sirtuin Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].

IC50 & Target

IC50: 0.01 μM (CypD); 1.1 μM (CypA); 0.21 μM (CypB); 0.31μM (CypE)[1]

In Vitro

CypD-IN-3 (B52) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC50 values of 0.01 μM, 1.1 μM, 0.21 μM and 0.31 μM, respectively[1].
CypD-IN-3 (10 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

972.09

Formula

C53H61N7O11

CAS No.
SMILES

NCCOCCNC([C@@H]1CCNC(/C=C/C(N2CCC[C@](C2)(C(N[C@H](C(NCC3=C(CC(N1)=O)C=CC=C3)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)CC(C(O)=O)C(O)=O)=O)CC6=CC=CC=C6)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CypD-IN-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CypD-IN-3
Cat. No.:
HY-151487
Quantity:
MCE Japan Authorized Agent: