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Ligelizumab

(Synonyms: QGE 031; Anti-IGHE Recombinant Antibody)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma).

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 1322627-61-1
  • Molecular Weight:146.32 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ligelizumab
  • Experimental Validation Results for Ligelizumab
  • Experimental Validation Results for Ligelizumab
  • Ligelizumab Chemical Structure
    Ligelizumab Chemical Structure
CAS No.: 1322627-61-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Ligelizumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IgE Fc Protein, Human can bind Ligelizumab. The EC50 for this effect is 4.31 ng/mL.

  • 1/16

    Loaded Ligelizumab on AHC2 biosensor, can bind IgE Protein, Human (HEK293, His, HY-P73907) with an affinity constant of 1.089E-12 M as determined in BLI assay.

  • Ligelizumab Chemical Structure
    1/16
  • Ligelizumab
  • Immobilized IgE Fc Protein, Human can bind Ligelizumab. The EC50 for this effect is 4.31 ng/mL.
  • Loaded Ligelizumab on AHC2 biosensor, can bind IgE Protein, Human (HEK293, His, HY-P73907) with an affinity constant of 1.089E-12 M as determined in BLI assay.