S1P1/EDG1 Antibody (YA1239)

Cat. No.: HY-P81494: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

S1P1/EDG1 Antibody (YA1239) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S1P1/EDG1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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S1P1/EDG1 Antibody (YA1239) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

S1P1/EDG1 Antibody (YA1239) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S1P1/EDG1.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 43 kDa;

Observed band size: 43 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P21453

Gene ID

1901 [NCBI]

Immunogen

A synthesized peptide derived from human EDG1

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Endosome; Membrane raft

Expression：
Tissue_specificity:Endothelial cells, and to a lesser extent, vascular smooth muscle cells, fibroblasts, melanocytes, and epithelioid cells.

Induction:By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide

Subunit：Interacts with GNAI1 and GNAI3. Interacts with CD69; this interaction promotes S1PR1 degradation (PubMed:37039481)

Database

Entrez Gene: 1901 Human

SwissProt: P21453 Human

OMIM: 601974 Human

Research Field

Cell Biology

Synonyms

S1PR1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; D1S3362

Documentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

S1P1/EDG1 Antibody (YA1239) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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S1P1/EDG1 Antibody (YA1239)

S1P1/EDG1 Antibody (YA1239) Featured Recommendations:

Product Detail

Background

Documentation

S1P1/EDG1 Antibody (YA1239) Related Classifications

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