2. Gene
  3. S1PR1 - sphingosine-1-phosphate receptor 1 Gene

S1PR1 - sphingosine-1-phosphate receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362

Gene ID: 1901 | Gene type: protein coding

About S1PR1

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:101,236,899-101,242,313 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 18 paralogues. Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues.

Summary

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

S1PR1 Products(9)

mRNA Protein Name
NR_174347.1
XR_007095678.1
NR_174349.1
NR_174346.1
NR_174348.1
NM_001320730.2 NP_001307659.1 sphingosine 1-phosphate receptor 1
NR_174350.1
NR_174345.1
NM_001400.5 NP_001391.2 sphingosine 1-phosphate receptor 1

S1PR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 311)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 1

S1P receptor 1

S1P receptor Edg-1

endothelial differentiation G-protein coupled receptor 1

endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

sphingosine 1-phosphate receptor EDG1

sphingosine 1-phosphate receptor Edg-1

Related Diseases

Diseases Alias
Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms

Relapsing Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Rrms

Multiple Sclerosis Relapsing-Remitting
Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder
Autoimmune Disease Of Central Nervous System
Herpes Zoster Oticus

Nervus Intermedius Neuralgia

Geniculate Herpes Zoster

Geniculate Neuralgia

Ramsay Hunt Syndrome Type 2

Herpes Zoster Auricularis

Herpetic Geniculate Ganglionitis

Ramsay Hunt Syndrome Type Ii

Ramsey Hunt Syndrome

Facial Nerve Palsy Due To Vzv

Facial Nerve Palsy Due To Herpes Zoster Infection

Facial Nerve Paralysis Due To Vzv

Hunt Syndrome

Hunt'S Syndrome

Ramsay Hunt Syndrome

Myoclonus And Ataxia
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Second-Degree Atrioventricular Block

Second-Degree Heart Block

Second Degree Atrioventricular Block

Second Degree Atrioventricular Heart Block

Second Degree Heart Block

Incomplete Atrioventricular Block, Second Degree Nos

Second-Degree Block, Type 1 And 2

Atrioventricular Block, Type 1 And 2

Second Degree Incomplete Atrioventricular Block

Av - [Atrioventricular] Block 2nd
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Progressive Multifocal Leukoencephalopathy

Pml

Leukoencephalopathy, Progressive Multifocal

Progressive Multifocal Leukoencephalitis

Leukoencephalopathy Progressive Multifocal

Pml - [Progressive Multifocal Leukoencephalopathy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 98.88% Yes
HY-12288 Ozanimod Agonist 99.88% Yes
HY-10569 Ponesimod Agonist 99.81% Yes
HY-12288A Ozanimod hydrochloride Modulator 99.19% Yes
HY-12355A Siponimod hemifumarate Agonist / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
HY-115831 SAR247799 Agonist 97.21% Phase 1
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W008947 SEW​2871 Agonist 99.77% Unkown
HY-136578 RP101988 Agonist 98.92% Unkown
HY-147660 IMMH001 Agonist / Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% Unkown
HY-136576 RP101075 Agonist / Unkown
HY-111253 CYM-5478 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown
HY-119245 Udifitimod Modulator / Unkown
HY-108492 TC-SP 14 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris S1PR1 VGNC VGNC:45836
Mus musculus S1PR1 MGD MGI:1096355
Rattus norvegicus S1PR1 RGD RGD:61958
Macaca mulatta S1PR1 VGNC VGNC:100129
Bos taurus S1PR1 VGNC VGNC:34252
Felis catus S1PR1 VGNC VGNC:64845