2. GPCR/G Protein
  3. LPL Receptor
  4. PF-462991

PF-462991 (PF-991) is a S1P1 receptor agonist with an EC50 of 1.9 nM. PF-462991 functionally activates this receptor via the β-arrestin pathway. PF-462991 is applicable to research related to rheumatoid arthritis.

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PF-462991

PF-462991 Chemical Structure

CAS No. : 1149727-90-1

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Other Forms of PF-462991:

PF-462991 Related Antibodies

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Description

PF-462991 (PF-991) is a S1P1 receptor agonist with an EC50 of 1.9 nM. PF-462991 functionally activates this receptor via the β-arrestin pathway. PF-462991 is applicable to research related to rheumatoid arthritis[1][2].

IC50 & Target[1]

S1PR1

1.9 nM (EC50)

In Vitro

PF-462991 potently activates the S1P1 receptor with an EC50 of 1.9 nM; in β-arrestin functional assays, its selectivity for the S1P1 receptor is over 5263-fold higher than that for the S1P3 receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-462991 Related Antibodies
Molecular Weight

419.53

Formula

C25H29N3O3
CAS No.
SMILES

[C@@H](N[C@H]1C[C@@H](C(O)=O)C1)(C)C2=CC=C(C=3N=C(ON3)C4=CC=C(CC(C)C)C=C4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-462991 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-4629911149727-90-1PF-991PF462991PF 462991PF991PF 991LPL ReceptorLysophospholipid ReceptorS1P1 receptorS1P3 receptorβ-arrestin pathwayrheumatoid arthritisInhibitorinhibitorinhibit

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