1149727-90-1
1149727-90-1
Chemical Structure
PF-462991
Synonym(s): PF-991
- CAS No.: 1149727-90-1
- Formula:C25H29N3O3
- Molecular Weight:419.53
IUPAC Name: (1S,3s)-3-(((R)-1-(4-(5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)amino)cyclobutane-1-carboxylic acid
InChIKey: JRZJZOSWCNBQFS-HVETUWLQSA-N
SMILES: [C@@H](N[C@H]1C[C@@H](C(O)=O)C1)(C)C2=CC=C(C=3N=C(ON3)C4=CC=C(CC(C)C)C=C4)C=C2
Biological Activity: PF-462991 (PF-991) is a S1P1 receptor agonist with an EC50 of 1.9 nM. PF-462991 functionally activates this receptor via the β-arrestin pathway. PF-462991 is applicable to research related to rheumatoid arthritis[1][2].
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PF-462991 | PF-462991 (PF-991) is a S1P1 receptor agonist with an EC50 of 1.9 nM. PF-462991 functionally activates this receptor via the β-arrestin pathway. PF-462991 is applicable to research related to rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Horan JC, et al. Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett. 2016;26(2):466-471. [Content Brief]
- [2]. Dyckman AJ, et al. Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives. J Med Chem. 2017;60(13):5267-5289. [Content Brief]
Keywords
