2. GPCR/G Protein
  3. LPL Receptor
  4. KSI-6666

KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model.

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KSI-6666

KSI-6666 Chemical Structure

CAS No. : 1807873-14-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

KSI-6666 Related Antibodies

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Description

KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].

IC50 & Target

S1PR1

6.4 nM (IC50)

Molecular Weight

454.91

Formula

C23H26ClF3N2O2
CAS No.
Appearance

Solid

Color

white

SMILES

CCN(C(C1=CC=C(C(CN2CC(C2)C(O)=O)=C1)C)C)C3=CC=C(C(C(F)(F)F)=C3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (91.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1982 mL 10.9912 mL 21.9824 mL
5 mM 0.4396 mL 2.1982 mL 4.3965 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1982 mL 10.9912 mL 21.9824 mL 54.9559 mL
5 mM 0.4396 mL 2.1982 mL 4.3965 mL 10.9912 mL
10 mM 0.2198 mL 1.0991 mL 2.1982 mL 5.4956 mL
15 mM 0.1465 mL 0.7327 mL 1.4655 mL 3.6637 mL
20 mM 0.1099 mL 0.5496 mL 1.0991 mL 2.7478 mL
25 mM 0.0879 mL 0.4396 mL 0.8793 mL 2.1982 mL
30 mM 0.0733 mL 0.3664 mL 0.7327 mL 1.8319 mL
40 mM 0.0550 mL 0.2748 mL 0.5496 mL 1.3739 mL
50 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0991 mL
60 mM 0.0366 mL 0.1832 mL 0.3664 mL 0.9159 mL
80 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6869 mL
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KSI-6666 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KSI-66661807873-14-8KSI6666KSI 6666LPL ReceptorLysophospholipid Receptororally activepseudo-irreversibleEAEautoimmune encephalomyelitiscolitiscompetitiveInhibitorinhibitorinhibit

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