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Cat. No.: HY-113934

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L-threo Lysosphingomyelin (d18:1)

Name: L-threo Lysosphingomyelin (d18:1)
Brand: MedChemExpress
SKU: HY-113934
Price: 478.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: L-threo-Sphingosylphosphorylcholine)

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Based on 1 Customer Validation

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC₅₀s of 19.3, 131.8, and 313.3 nM for hS1P₁, hS1P₃, and hS1P₂, respectively.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 105615-55-2
Formula: C₂₃H₄₉N₂O₅P
Molecular Weight:464.62

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-threo Lysosphingomyelin (d18:1) Chemical Structure

CAS No.: 105615-55-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

S1PR1

19.3 nM (EC₅₀, human)

S1PR3

131.8 nM (EC₅₀, human)

S1PR2

313.3 nM (EC₅₀, human)

All LPL Receptor Isoforms :

Chemical Information

CAS No. 105615-55-2
Appearance Solid
Molecular Weight 464.62
Formula C₂₃H₄₉N₂O₅P
Color White to off-white
SMILES

O=P(OCC[N+](C)(C)C)(OC[C@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC)[O-]
Synonyms

L-threo-Sphingosylphosphorylcholine
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Im DS, et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 2001;40(46):14053-14060. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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L-threo Lysosphingomyelin (d18:1)

Siponimod

Ponesimod

CAY10444

2-Acetyl-4-tetrahydroxybutyl imidazole

Sphinganine 1-phosphate

RP-001 hydrochloride

C16-Sphingosine-1-phosphate

Siponimod (Standard)

Ponesimod (Standard)

CYM5442 hydrochloride

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

L-threo Lysosphingomyelin (d18:1)

Siponimod

Ponesimod

CAY10444

2-Acetyl-4-tetrahydroxybutyl imidazole

Sphinganine 1-phosphate

RP-001 hydrochloride

C16-Sphingosine-1-phosphate

Siponimod (Standard)

Ponesimod (Standard)

CYM5442 hydrochloride

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L-threo Lysosphingomyelin (d18:1) Related Classifications

HY-113934 Related Classifications

Bioz