1. GPCR/G Protein
  2. LPL Receptor
  3. RP-001 hydrochloride

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

For research use only. We do not sell to patients.

RP-001 hydrochloride Chemical Structure

RP-001 hydrochloride Chemical Structure

CAS No. : 1781880-34-9

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Description

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

In Vitro

RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.93

Formula

C24H25ClN4O4

CAS No.
SMILES

O=C(O)CCNC1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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RP-001 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RP-001 hydrochloride
Cat. No.:
HY-101939A
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