Sphingomyelins

Sphingomyelins (26):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

N-Palmitoyl-D-sphingomyelin	6254-89-3	99.90%
N-palmitoyl-D-sphingomyelin (sphingomyelin 16:0) is a component of LDL-carrying liposomes. N-palmitoyl-D-sphingomyelin can be used in colorectal cancer research.

C6 NBD Sphingomyelin	94885-04-8	98.0%
C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane.

Sphingomyelin (d18:1/12:0)	474923-21-2	99.0%
Sphingomyelin (d18:1/12:0) is a metabolomic biomarker. Sphingomyelin (d18:1/12:0) exhibits favorable diagnostic properties and may facilitate the early detection and targeted prevention of dyslipidemia-related adverse cardiovascular events.

Sphingomyelins, milk	475662-40-9	99.20%
Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes.

C12 NBD Sphingomyelin	254117-01-6	99.0%
C12 NBD sphingomyelin is an active derivative of Sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm).

N-Stearoylsphingomyelin	58909-84-5	98.60%
N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) is a sphingolipid, which can inhibit Phospholipase Cδ1 (PLCδ1).

N-Palmitoyldihydrosphingomyelin	60322-02-3	99%
N-Palmitoyldihydrosphingomyelin (16:0 Dihydro SM (d18:0/16:0)) is a dihydrosphingomyelin.

N-Nervonoyl-D-erythro-sphingosylphosphorylcholine	94359-13-4	99.0%
N-Nervonoyl-D-erythro-sphingosylphosphorylcholine is a biochemical reagent.

L-threo Lysosphingomyelin (d18:1)	105615-55-2	98.0%
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC₅₀s of 19.3, 131.8, and 313.3 nM for hS1P₁, hS1P₃, and hS1P₂, respectively.

C20 Sphingomyelin (d18:1/20:1)	222403-67-0
C20 Sphingomyelin (d18:1/20:1) is a sphingomyelin substance. The level of C20 Sphingomyelin (d18:1/20:1) is associated with amyotrophic lateral sclerosis and primary lateral sclerosis.

C18 Sphingomyelin (d18:1/18:0)	54336-69-5	98%
C18 Sphingomyelin (d18:1/18:0) is a form of sphingomyelin and can be used for study of sphingolipid metabolites.

C17 Sphingomyelin (d18:1/17:0)	121999-64-2	99.67%
C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.

SM (d18:1/15:0)	121999-58-4
SM (d18:1/15:0) is a sphingomyelinase inhibitor. SM (d18:1/15:0) is promising for research of neurodegenerative diseases (e.g., Alzheimer's) and metabolic syndrome.

14:0 Dihydro SM (d18:0/14:0)	871577-10-5
14:0 Dihydro SM (d18:0/14:0) is a sphingomyelin.

C20 Sphingomyelin (d18:1/20:0)	121999-68-6
C20 Sphingomyelin (d18:1/20:0) (N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)) is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) levels are upregulated in the hippocampus of streptozotocin (HY-13753)-induced diabetic rats and in human plasma, positively correlating with insulin resistance in obese humans. C20 Sphingomyelin (d18:1/20:0) is also upregulated in the liver of a mouse model of Niemann-Pick C1 disease, a neurodegenerative cholesterol sphingolipid lysosomal storage disorder.

CerPCho (d18:0/22:0)	221097-58-1
CerPCho (d18:0/22:0) is a sphingomyelin with a d18:0-type sphingosine long-chain base and a 22:0-type N-acyl fatty acid.

28:0 SM (d18:1/28:0)	1425088-71-6
28:0 SM (d18:1/28:0) is a lycerophospholipid.

N-Lauroyl-D-erythro-sphinganylphosphorylcholine	474923-31-4
N-Lauroyl-D-erythro-sphinganylphosphorylcholine is a phosphosphingolipid.

N-Lignoceroyl-D-erythro-sphingosylphosphorylcholine	60037-60-7
N-Lignoceroyl-D-erythro-sphingosylphosphorylcholine is a phosphosphingolipid.

16:1 SM (d18:1/16:1)	222403-66-9
16:1 SM (d18:1/16:1) is a phosphosphingolipid.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

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