1. GPCR/G Protein
  2. LPL Receptor
  3. Cenerimod

Cenerimod (Synonyms: ACT-334441)

Cat. No.: HY-17606 Purity: 98.02%
Handling Instructions

Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.

For research use only. We do not sell to patients.

Cenerimod Chemical Structure

Cenerimod Chemical Structure

CAS No. : 1262414-04-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
25 mg USD 249 In-stock
Estimated Time of Arrival: December 31
50 mg USD 435 In-stock
Estimated Time of Arrival: December 31
100 mg USD 739 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.

IC50 & Target

EC50: 2.7 nM[2]

Clinical Trial
Molecular Weight

453.53

Formula

C₂₅H₃₁N₃O₅

CAS No.

1262414-04-9

SMILES

OC[[email protected]](O)COC1=C(C)C=C(C2=NOC(C3=CC(C4CCCC4)=NC(OC)=C3)=N2)C=C1CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (220.49 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2049 mL 11.0246 mL 22.0493 mL
5 mM 0.4410 mL 2.2049 mL 4.4099 mL
10 mM 0.2205 mL 1.1025 mL 2.2049 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.02%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CenerimodACT-334441ACT334441ACT 334441LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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Product name:
Cenerimod
Cat. No.:
HY-17606
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