2. GPCR/G Protein
  3. LPL Receptor
  4. CS1P1

CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC50 values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation.

For research use only. We do not sell to patients.

CS1P1

CS1P1 Chemical Structure

CAS No. : 1246526-29-3

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CS1P1 Related Antibodies

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Description

CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC50 values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation[1][2][3].

IC50 & Target[1]

S1PR1

2.1 nM (IC50)

In Vitro

CS1P1 (2 h) potently binds to recombinant human S1PR1 with an IC50 of 2.1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CS1P1 Related Antibodies
In Vivo

CS1P1 (0.3 mg/kg; i.v.; single bolus) is well tolerated in male and female Sprague Dawley rats, with no observable adverse effects identified over 15 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male and female)[2]
Dosage: 0.3 mg/kg
Administration: i.v.; single bolus
Result: Allowed all rats to survive to scheduled euthanasia.
Caused no CS1P1-related effects on body weights, hematology parameters, clinical chemistry parameters, organ weights, or gross pathology findings at either Day 2 or Day 15.
Showed no CS1P1-related histopathology.
Molecular Weight

513.48

Formula

C27H23F4N3O3
CAS No.
SMILES

O=C(CCN(CC1=C(F)C=C(C2=NOC(C3=CC(C(F)(F)F)=C(C4=C(C)C=CC=C4)C=C3)=N2)C=C1)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CS1P1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS1P11246526-29-3LPL ReceptorLysophospholipid Receptorrelapsing-remitting multiple sclerosisnonhuman primate brain gray matterblood-brain barrierinflammatory diseasesneointimal hyperplasiamultiple sclerosisS1PR1ratscynomolgus macaquesvascular inflammationInhibitorinhibitorinhibit

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