1246526-29-3
Chemical Structure
CS1P1
- CAS No.: 1246526-29-3
- Formula:C27H23F4N3O3
- Molecular Weight:513.48
InChIKey: WGQKJRQXCSGORT-UHFFFAOYSA-N
SMILES: O=C(CCN(CC1=C(F)C=C(C2=NOC(C3=CC(C(F)(F)F)=C(C4=C(C)C=CC=C4)C=C3)=N2)C=C1)C)O
Biological Activity: CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC50 values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation[1][2][3].
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CS1P1 | CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC50 values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation. | |||||||||||||||||||||
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- [1]. Qiu L, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023;66(7):4671-4688. [Content Brief]
- [2]. Liu H, et al. Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1. Mol Imaging Biol. 2020;22(2):285-292. [Content Brief]
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[3]. Castelo GP, et al. Pharmacological characterization of the CS1P1 compound as a S1P1 receptor antagonist. Ibro Neurosci Rep. 2023 Oct;15:S473-S474.
Keywords
