1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. LY3154207

LY3154207 

Cat. No.: HY-128770
Handling Instructions

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).

For research use only. We do not sell to patients.

LY3154207 Chemical Structure

LY3154207 Chemical Structure

CAS No. : 1638667-79-4

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Description

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1].

IC50 & Target

EC50: 3 nM (human dopamine D1 receptor)[1]

In Vitro

In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC50s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively[1].

Molecular Weight

450.40

Formula

C₂₄H₂₉Cl₂NO₃

CAS No.

1638667-79-4

SMILES

O=C(N1[[email protected]@H](C)C2=C(C(CCC(C)(O)C)=CC=C2)C[[email protected]@H]1CO)CC3=C(Cl)C=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LY3154207LY 3154207LY-3154207Dopamine ReceptorInhibitorinhibitorinhibit

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