p-F-HHSiD hydrochloride
Based on 1 Customer Validation
p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 175615-76-6
- Formula: C20H33ClFNOSi
- Molecular Weight:386.02
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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mAChR3 |
mAChR5 |
mAChR1 |
mAChR2 |
mAChR4 |
α1-adrenergic receptor |
p-F-HHSiD (30 nM-10 μM, 60-180 mins) exerts an antagonistic effect on M3 receptor-mediated contractile responses in tracheal tissue of guinea pigs[1].
p-F-HHSiD (100 μM, 5 days) inhibits basal proliferation of H508 human colon cancer cells by 40% through selective blocking of M3 muscarinic receptors[2].
p-F-HHSiD (0.03-3 μM) significantly inhibits the positive phase of inotropic response to Ach in isolated mouse left atria[3].
p-F-HHSiD (0.1 nM-100 μM, 90 mins) exhibits a single class of binding sites to muscarinic receptors in P2 crude synaptosomal fractions from frontal cortices (Alzheimer’s disease brains)[4].
p-F-HHSiD (1 μM, 2 h) significantly inhibits ACh-induced contraction of isolated human umbilical vein (HUV) (gestational diabetes mellitus)[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 175615-76-6
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Appearance Solid
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Molecular Weight 386.02
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Formula C20H33ClFNOSi
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Color White to off-white
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SMILES
O[Si](C1=CC=C(F)C=C1)(C2CCCCC2)CCCN3CCCCC3.[H]Cl
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Synonyms
p-Fluorohexahydrosiladifenidol hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. [Content Brief]
[2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7. [Content Brief]
[3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15. [Content Brief]
[4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8. [Content Brief]
[5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308. [Content Brief]
[6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p-F-HHSiD hydrochloride Related Classifications
HY-137388A Related Classifications
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