175615-76-6
Chemical Structure
p-F-HHSiD hydrochloride
Synonym(s): p-Fluorohexahydrosiladifenidol hydrochloride
- CAS No.: 175615-76-6
- Formula:C20H33ClFNOSi
- Molecular Weight:386.02
InChIKey: JMTYYLMGSBSPPK-UHFFFAOYSA-N
SMILES: O[Si](C1=CC=C(F)C=C1)(C2CCCCC2)CCCN3CCCCC3.[H]Cl
Biological Activity: p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes[1][2][3][4][5][6].
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p-F-HHSiD hydrochloride | 99.0% | p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes. | ||||||||||||||||||||
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References
- [1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. [Content Brief]
- [2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7. [Content Brief]
- [3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15. [Content Brief]
- [4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8. [Content Brief]
- [5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308. [Content Brief]
- [6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71. [Content Brief]
