p-F-HHSiD
p-F-HHSiD (p-Fluorohexahydrosiladifenidol) is a potent and selective M3 mAChR antagonist. p-F-HHSiD has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 116679-83-5
- Formula: C20H32FNOSi
- Molecular Weight:349.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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mAChR1 |
mAChR2 |
mAChR3 |
mAChR4 |
mAChR5 |
α1-adrenergic receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | EC50 |
5.815 μM
Compound: 8, p-F-HHSiD
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Antiproliferative activity against mouse astrocyte cells by MTT assay
Antiproliferative activity against mouse astrocyte cells by MTT assay
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[PMID: 17417631] |
| Medulloblastoma cell | EC50 |
1.125 μM
Compound: 8, p-F-HHSiD
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Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay
Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay
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[PMID: 17417631] |
Chemical Information
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CAS No. 116679-83-5
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Molecular Weight 349.56
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Formula C20H32FNOSi
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SMILES
FC1=CC=C([Si](CCCN2CCCCC2)(C3CCCCC3)O)C=C1
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Synonyms
p-Fluorohexahydrosiladifenidol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. [Content Brief]
[2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7. [Content Brief]
[3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15. [Content Brief]
[4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8. [Content Brief]
[5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308. [Content Brief]
[6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p-F-HHSiD Related Classifications
HY-137388 Related Classifications
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