116679-83-5
Chemical Structure
p-F-HHSiD
Synonym(s): p-Fluorohexahydrosiladifenidol
- CAS No.: 116679-83-5
- Formula:C20H32FNOSi
- Molecular Weight:349.56
IUPAC Name: cyclohexyl(4-fluorophenyl)(3-(piperidin-1-yl)propyl)silanol
InChIKey: ZNSZQJHTFRQUPD-UHFFFAOYSA-N
SMILES: FC1=CC=C([Si](CCCN2CCCCC2)(C3CCCCC3)O)C=C1
Biological Activity: p-F-HHSiD (p-Fluorohexahydrosiladifenidol) is a potent and selective M3 mAChR antagonist. p-F-HHSiD has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes[1][2][3][4][5][6].
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p-F-HHSiD | p-F-HHSiD (p-Fluorohexahydrosiladifenidol) is a potent and selective M3 mAChR antagonist. p-F-HHSiD has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes. | |||||||||||||||||||||
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References
- [1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. [Content Brief]
- [2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7. [Content Brief]
- [3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15. [Content Brief]
- [4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8. [Content Brief]
- [5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308. [Content Brief]
- [6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71. [Content Brief]
