L-Glutamic acid monosodium hydrate

Name: L-Glutamic acid monosodium hydrate
Brand: MedChemExpress
SKU: HY-W016145
Rating: 4.5 (1 reviews)

Cat. No.: HY-W016145 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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L-Glutamic acid monosodium hydrate is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium hydrate has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium hydrate can be used in the study of neurological diseases. L-Glutamic acid monosodium hydrate acts at ionotropic and?metabotropic glutamate receptors.

For research use only. We do not sell to patients.

L-Glutamic acid monosodium hydrate Chemical Structure

CAS No. : 6106-04-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Glutamic acid monosodium hydrate:

L-Glutamic acid-¹³C₅ hydrate salt Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

L-Glutamic acid (120-1000 mg/dL) monosodium hydrate can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus^[3].
L-Glutamic acid (2-20 mM, 24-48 h) monosodium hydrate can induce neuroexcitotoxicity in neuroblastoma^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	SH-SY5Y, IMR-32, SK-N-BE(2)
Concentration:	2, 5, 10, 20 mM
Incubation Time:	24 and 48 h
Result:	Reduced cell viability in a dose-dependent manner.

In Vivo

L-Glutamic acid (3 g/kg, subcutaneous injection, single dose) monosodium hydrate can promote excitotoxic degeneration of retinal ganglion cells in mice^[1].
L-Glutamic acid (750 mg/kg, intraperitoneal injection) monosodium hydrate can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Crv4 mice model^[1]
Dosage:	3 g/kg
Administration:	s.c., single dose
Result:	Reduced the number of Brn-3a⁺ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.

Molecular Weight

187.13

Formula

C₅H₁₀NNaO₅

CAS No.

6106-04-3

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CCC(O)=O)N)O[Na].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (534.39 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3439 mL	26.7194 mL	53.4388 mL
5 mM	1.0688 mL	5.3439 mL	10.6878 mL
10 mM	0.5344 mL	2.6719 mL	5.3439 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (130 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149. [Content Brief]

[2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. [Content Brief]

[3]. Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132. [Content Brief]

[4]. Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30. [Content Brief]

[5]. Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.3439 mL	26.7194 mL	53.4388 mL	133.5970 mL
	5 mM	1.0688 mL	5.3439 mL	10.6878 mL	26.7194 mL
	10 mM	0.5344 mL	2.6719 mL	5.3439 mL	13.3597 mL
	15 mM	0.3563 mL	1.7813 mL	3.5626 mL	8.9065 mL
	20 mM	0.2672 mL	1.3360 mL	2.6719 mL	6.6798 mL
	25 mM	0.2138 mL	1.0688 mL	2.1376 mL	5.3439 mL
	30 mM	0.1781 mL	0.8906 mL	1.7813 mL	4.4532 mL
	40 mM	0.1336 mL	0.6680 mL	1.3360 mL	3.3399 mL
	50 mM	0.1069 mL	0.5344 mL	1.0688 mL	2.6719 mL
	60 mM	0.0891 mL	0.4453 mL	0.8906 mL	2.2266 mL
	80 mM	0.0668 mL	0.3340 mL	0.6680 mL	1.6700 mL
	100 mM	0.0534 mL	0.2672 mL	0.5344 mL	1.3360 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.