CACNA2D1 Protein, Human (His-SUMO)
The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
The CACNA2D1 protein, specifically its alpha-2/delta subunit, assumes a pivotal role in the regulation of calcium current density and the activation/inactivation kinetics of voltage-dependent calcium channels. It plays a crucial part in excitation-contraction coupling, contributing to the coordination of cellular processes. The alpha-2/delta subunit forms a dimer with alpha-2-1 and delta-1 chains through disulfide linkage, constituting an essential structural component of voltage-dependent calcium channels. These channels are intricate multisubunit complexes, composed of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB), and delta (CACNA2D) subunits in a 1:1:1:1 ratio. The functional and structural involvement of CACNA2D1 underscores its significance in the precise modulation of calcium signaling and cellular responses.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His;N-SUMO
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Accession
P54289 (Q528-N668)
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Molecular Construction
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N-term
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6*His-SUMO
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CACNA2D1 (Q528-N668)
Accession # P54289 -
C-term
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Protein Length
Partial
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Synonyms
CACNA2D1; Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1; Prev. CACNL2A; CCHL2A; Prev. LINC01112; Dihydropyridine-Sensitive L-Type, Calcium Channel Alpha-2/Delta Subunit; Prev. CACNA2; Calcium Channel, L Type, Alpha 2 Polypeptide; Prev. MHS3; L
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AA Sequence
QPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCN
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Predicted Molecular Mass
32.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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