2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. VGSC blocker-1

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability.

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VGSC blocker-1 Chemical Structure

VGSC blocker-1 Chemical Structure

CAS No. : 2230472-55-4

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VGSC blocker-1 Related Antibodies

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Description

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability[1].

IC50 & Target

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5)[1].
In Vitro

VGSC blocker 1 (compound 1) (1.0 to 10 μM) inhibits human breast cancer cell line MDA-MB-231[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VGSC blocker-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: human breast cancer cell line MDA-MB-231
Concentration: 1.0 to 10μM
Incubation Time: 24 hours
Result: VGSC blocker 1 blocks INa peak currents 34.9% at 1 uMa and inhibits cell invasion 0.3% at 1 uM. These values are much higher than the concentrations required (0.1 μM and 1 μM) to produce significant nNav1.5 current blockade and cell invasion inhibition.
Molecular Weight

386.52

Formula

C24H32F2N2
CAS No.
SMILES

FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCCCN3CCCCC3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VGSC blocker-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VGSC blocker-12230472-55-4VGSC blocker1VGSC blocker 1Sodium ChannelNa channelsNa+ channelssmall molecule blockerneonatal isoformVGSC subtypehuman breast cancerMDA-MB-231Inhibitorinhibitorinhibit

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