VGSC blocker-1 

Cat. No.: HY-126005
Handling Instructions

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability.

For research use only. We do not sell to patients.

VGSC blocker-1 Chemical Structure

VGSC blocker-1 Chemical Structure

CAS No. : 2230472-55-4

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Description

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability[1].

IC50 & Target

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5)[1].

In Vitro

VGSC blocker 1 (1.0 to 10μM) inhibits human breast cancer cell line MDA-MB-231[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: human breast cancer cell line MDA-MB-231
Concentration: 1.0 to 10μM
Incubation Time: 24 hours
Result: VGSC blocker 1 blocks INa peak currents 34.9% at 1 uMa and inhibits cell invasion 0.3% at 1 uM. These values are much higher than the concentrations required (0.1 μM and 1 μM) to produce significant nNav1.5 current blockade and cell invasion inhibition.
Molecular Weight

386.52

Formula

C₂₄H₃₂F₂N₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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VGSC blocker-1
Cat. No.:
HY-126005
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